OTX1 Gene - GeneCards | OTX1 Protein | OTX1 Antibody
网页2024年8月6日 — OTX1 (Orthodenticle Homeobox 1) is a Protein Coding gene. Diseases associated with OTX1 include Autism Spectrum Disorder and Prostate Leiomyoma. Among its related pathways are Beta-2 adrenergic-dependent CFTR expression and Transcriptional Regulatory Network in Embryonic Stem Cell.
Otx1 and Otx2 in the development and evolution of the …
网页1998年12月1日 — Human Otx1 and Otx2 genes complement the otd defects allowing the rescue of brain, ventral nerve cord and cephalic defects in Drosophila. Moreover, their ubiquitous overexpression in the fly is able to induce …
OTX1 - Wikipedia
网页Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene. [ 5][ 6] Function. This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development.
OTX1 is a novel regulator of proliferation, migration, invasion and ...
网页Silencing the OTX1 gene suppressed the proliferation, migration and invasion of NCI-H292 and XWLC cells, impeded the cell cycle transition from G2 to M phase, and accelerated apoptosis, revealing OTX1, a regulator of NSCLC, as a potential new therapeutic target.
OTX1 regulates cell cycle progression of neural progenitors in the ...
网页Otx1 knockdown by in utero electroporation in the mouse brain reduced the proportion of the G 1 phase while increasing the S and M phases of progenitor cells. The knockdown diminished Tbr1+ neurons but increased GFAP+ astrocytes in the early postnatal cortex as revealed by lineage tracing study.
OTX1 regulates tumorigenesis and metastasis in glioma
网页2024年2月1日 — OTX1 shows high expression levels in tissues including neuroblastoma, breast cancer, colon cancer, and gallbladder cancer [10], [11], [12], [13]. This suggests that OTX1 could potentially serve as a novel target for tumor gene therapy.
OTX1 regulates cell cycle progression of neural progenitors in the ...
网页2018年2月9日 — Otx1 is one of the homeobox-containing transcription factors frequently implicated in the development of the central nervous system. Mice bearing a targeted deletion of Otx1 exhibit brain hypoplasia and a decrease in the number of cortical neurons.
OTX1 promotes tumorigenesis and progression of cervical cancer …
网页2022年9月29日 — Orthodenticle homolog 1 (OTX1) serves a key role in the occurrence and progression of tumors. The present study aimed to investigate the role and potential mechanism of OTX1 in cervical cancer. OTX1 expression was analyzed by western blotting, reverse transcription-quantitative PCR and immunohistochemistry.
OTX Genes in Adult Tissues - PMC - National Center for …
网页2023年11月30日 — Orthodenticle homeobox protein 1 and 2 (OTX1 and OTX2) are transcription factors encoded by homeobox-containing genes, embedded in humans on chromosomes 2p13 and 14q21-22, respectively [1].
OTX1 exerts an oncogenic role and is negatively regulated by …
网页2020年8月24日 — Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We aimed to explore the roles of OTX1 in LSCC and its possible molecular mechanism. Methods.
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