2B4 (CD244) is a non-MHC binding receptor with multiple …
网页2B4 (CD244) is expressed by memory-phenotype CD8 (+) T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and a number of reports have linked 2B4 with activation of lymphocytes. We have employed 2B4-deficient mice and antibody blocking to analyze 2B4 ...
CD244 - Wikipedia
网页CD244 (Cluster of Differentiation 244) also known as 2B4 or SLAMF4 is a protein that in humans is encoded by the CD244 gene. [5] CD244 is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule family of receptors (SLAMF) which are expressed in different types of hematopoietic cells. [6]
2B4: an NK cell activating receptor with unique specificity
网页2B4 is a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM. Engagement of 2B4 on NK cells with specific antibodies or with its ligand CD48 enhances NK cell-mediated cytotoxicity. 2B4 is also expressed on both CD8+ ….
免疫检查点的糖基化及其在肿瘤中的应用 - 知乎
网页2b4 (cd244)是信号通路淋巴细胞活化分子相关受体家族中的一种细胞表面糖蛋白，在所有nk细胞、cd8+ t细胞和树突状细胞上均有表达，参与nk细胞和t细胞功能的调节。
Functional role of human NK cell receptor 2B4 (CD244) isoforms
网页2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM/CD150), is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. Human NK cells express two isoforms of 2B4, h2B4-A and h2B4-B that differ in a small portion of the extracellular domain.
Roles of NK Cell Receptors 2B4 (CD244), CS1 (CD319), and LLT1 …
网页2020年7月1日 · The 2B4 receptor is involved in the rejection of melanoma cells in mice. Empliciti, an FDA-approved monoclonal antibody, explicitly targets the CS1 receptor and enhances the NK cell cytotoxicity against multiple myeloma cells.
2B4, the Natural Killer and T Cell Immunoglobulin Superfamily …
网页1998年12月12日 · 2B4 is a cell surface glycoprotein related to CD2 and implicated in the regulation of natural killer and T lymphocyte function. A recombinant protein containing the extracellular region of mouse (m)2B4 attached to avidin-coated fluorescent beads bound to rodent cells, and binding was completely blocked by CD48 monoclonal antibodies (mAbs).
2B4: an NK cell activating receptor with unique ... - ScienceDirect
网页2000年1月1日 · 2B4 is a cell surface glycoprotein of the Ig-superfamily that enhances NK cell-mediated cytotoxicity and cytokine secretion. It binds to CD48 and recruits SAP, a SH2-containing adapter molecule, to activate NK cells.
Molecular Basis of the Dual Functions of 2B4 (CD244)1
网页2008年6月15日 · 2B4 belongs to the CD2 family of molecules and is expressed on all NK, γδ, and memory CD8 + (αβ) T cells. The murine NK receptor 2B4 exhibits both inhibitory and activating functions, whereas human 2B4 has been reported to be an activating molecule.
Molecular Dissection of 2B4 Signaling: Implications for Signal ...
网页2B4 is a SLAM-related receptor expressed on natural killer (NK) cells and cytotoxic T cells. It can regulate killing and gamma interferon secretion by NK cells, as well as T-cell-mediated cytotoxicity. There are conflicting data regarding the mechanism of action of 2B4.
跳至内容