2-Methoxyestradiol - Wikipedia
网页2-Methoxyestradiol (2-ME2, 2-MeO-E2) is a natural metabolite of estradiol and 2-hydroxyestradiol (2-OHE2). It is specifically the 2- methyl ether of 2-hydroxyestradiol. 2-Methoxyestradiol prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis), hence it is an angiogenesis inhibitor. [1] .
2-Methoxyestradiol (2-ME2，二甲氧基雌二醇) - MCE-生物活性 ...
网页2019年8月7日 · 2-Methoxyestradiol (2-ME2)，具有口服活性的 17β-雌二醇 (E2) 的内源性代谢产物，是凋亡 (apoptosis) 诱导剂和血管生成 (angiogenesis) 抑制剂，具有有效的抗肿瘤活性。 2-Methoxyestradiol 也可破坏微管 (microtubules) 的稳定。 2-Methoxyestradiol 是一种有效的超氧化物歧化酶 (SOD) 抑制剂和活性氧生成剂，可诱导转化细胞系 HEK293、癌细胞系 U87 和 HeLa 的自噬 (autophagy)。 MCE 的所有产品仅用作科学研究或药证申报，我们不 …
2-Methoxyestradiol (2-MeOE2) | 2-甲氧雌二醇 | 购买HIF 抑制剂
网页2-Methoxyestradiol (2-MeOE2, NSC 659853, NSC 659853, 2-ME2) 使微管解聚，并抑制 HIF-1α 核积累以及HIF转录活性。. 2-Methoxyestradiol 可在多种致癌细胞系中诱导自噬和凋亡。. 2-Methoxyestradiol (2-MeOE2) Chemical Structure. CAS: 362-07-2. 规格.
2-Methoxyestradiol - DrugBank Online
网页2005年6月13日 · 2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis. Type.
2-Methoxyestradiol | C19H26O3 | CID 66414 - PubChem
网页2-Methoxyestradiol (2ME2) is a drug that prevents the formation of new blood vessels that tumors need in order to grow (angiogenesis). It has undergone Phase 1 clinical trials against breast cancers and preclinical studies suggest that 2ME2 could also be effective against inflammatory diseases such as rheumatoid arthritis.
Correlation of 2-Methoxyestradiol Levels in Cord Blood and
网页2-methoxyestradiol (2ME2) is a potent antiangiogenic molecule that inhibits the expression of hypoxia-inducible factor (HIF)-1α and, consequently, of VEGF and other HIF-1α...
2-甲氧基雌二醇可通过阻断NF-κB和CCAAT /增强子结合蛋白β的活 …
网页2ME2可抑制IgG IC攻击的巨噬细胞中的NF-κB和CCAAT /增强子结合蛋白（C / EBP）β。 我们证明减轻NF-κB依赖性转录可能与减少NF-κBp65的磷酸化有关，并且C / EBP激活的减少直接与其表达有关。 此外，我们发现2ME2减轻了IgG IC刺激的p38 MAPK和ERK1 / 2的磷酸化。 这些数据表明了一种阻断IgG IC诱导的炎症活性的新策略。 2ME2可抑制IgG IC攻击的巨噬细胞中的NF-κB和CCAAT /增强子结合蛋白（C / EBP）β。 我们证明减轻NF-κB依赖性 …
Mechanism of action of 2-methoxyestradiol: new developments
网页2-Methoxyestradiol (2ME2) is an endogenous metabolite of estrogen that has both antiangiogenic and antitumor effects. In preclinical models, 2ME2 showed promising activity that led to its clinical development as an orally …
2-Methoxyestradiol protects against IgG immune complex …
网页2017年5月1日 · Highlights. •. 2ME2 inhibits IgG IC-induced acute lung injury. •. 2ME2 blocks NF-κB and C/EBPβ activation in IgG IC-treated macrophages. •. 2ME2 reduces p38 MAPK and ERK1/2 activities in macrophages challenged by IgG IC. •. The MAPKs positively regulate C/EBPβ expression in macrophages treated with IgG IC. Abstract.
2-Methoxyestradiol | 362-07-2 | 美国AbMole | 2ME2
网页2-Methoxyestradiol (2-MeOE2)使微管解聚，且抑制HIF-1α核积累和HIF转录活性。. 2-Methoxyestradiol作用于乳腺癌细胞系 MDA-MB-435和卵巢癌细胞系SK-OV-3，抑制细胞增殖，IC50分别为 1.38 μM 和 1.79 μM。而且, 2-Methoxyestradiol作用于大鼠主动脉平滑肌A-10细胞，也抑制细胞微管解聚，EC50 ...
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