Acetyltransferase - Wikipedia
网页An acetyltransferase (also referred to as a transacetylase) is a type of transferase enzyme that transfers an acetyl group, through a process called acetylation.
组蛋白去乙酰化酶 - 百度百科
网页组蛋白去乙酰化酶 (histone deacetylase,HDAC)是一类蛋白酶,对染色体的结构修饰和基因表达调控发挥着重要的作用。 一般情况下,组蛋白的乙酰化有利于DNA与组蛋白八聚体的解离，核小体结构松弛，从而使各种转录因子和协同转录因子能与DNA结合位点特异性结合，激活基因的转录。 而组蛋白的去乙酰化则发挥相反的作用。 中文名. 组蛋白去乙酰化酶. 外文名. histone deacetylase,HDAC. 实 质. 一类蛋白酶. 作 用. 染色体的结构修饰和 基因表达调控. …
Mechanisms, Detection, and Relevance of Protein Acetylation in ...
网页2019年4月9日 · Protein acetylation occurs through a nucleophilic acyl substitution reaction between a nucleophile and an activated acetyl group (CH 3 CO-X), which is typically in the form of acetyl coenzyme A (AcCoA) or acetyl phosphate (AcP) (12).
Histone acetylation and the role of histone deacetylases in …
网页2020年8月13日 · Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation.
乙酰化酶 - 百度百科
网页乙酰化酶（acetyltransferase），或称 组蛋白乙酰转移酶 （histoneacetyltransferase，HAT），是使组蛋白乙酰基化，减弱组蛋白与 DNA 的紧密结合能力，促进转录的酶。 研究表明HAT活性异常可导致从神经性病变到 癌症 等多种疾病的发生。 组蛋白乙酰转移酶（HAT）及 组蛋白去乙酰化酶 （HDAC）调节组蛋白和转录因子的乙酰化水平，从而在控制细胞生命活动中发挥着重要作用。 生理功能. 播报. 编辑. 在 细胞核 …
A short guide to histone deacetylases including recent progress …
网页2020年2月19日 · Histones can be modified by the acetylation or deacetylation of lysine residues by HATs or HDACs to regulate the interaction between histones and DNA. The …
Acetyltransferase - an overview | ScienceDirect Topics
网页Acetyltransferases are one of the leading groups of enzymes which also involved in post-translational modifications. Acetylation plays important role in response to extracellular signals in regulating cellular processes. The review focused on catalytic mechanism, complexes and inhibitors of acetyl transferases in fungal genera.
Regulation by Acetylation | Science's STKE - AAAS
网页2000年3月21日 · Acetylase substrates now include transcription factors, nuclear import factors, and cytoskeletal proteins. Kouzarides provides a succinct overview of the enzymes and their specificity and regulation, as well as a discussion of substrates and functional consequences of protein acetylation.
Acetylase Definition & Meaning | Merriam-Webster Medical
网页The meaning of ACETYLASE is any of a class of enzymes that accelerate the synthesis of acetic acid esters (as acetylcholine).
Acetylation - an overview | ScienceDirect Topics
网页Acetylation refers to a reversible modification on proteins, particularly lysine residues in histone proteins, that can influence chromatin structure and gene expression levels. This process is extensively studied in molecular and cell biology, although the functional consequences of acetylation on other proteins are not well understood.