Leptin as a key regulator of the adipose organ
网页2021年9月14日 · Leptin is able to activate lipolysis in white adipose tissue (WAT), by the increase of ATGL (adipose triglyceride lipase) and HSL (hormone sensitive lipase) expression, both acting centrally activating sympathetic nervous system (SNS) and by a direct action on WAT, through β-adrenergic receptors (β-AR).
Leptin as a key regulator of the adipose organ - PMC
网页2021年9月14日 · Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin is also produced by other tissues, such as the stomach, placenta, and mammary gland.
Leptin and brain–adipose crosstalks - Nature
网页2018年2月16日 · Adipose tissue has a central role in leptin production and in the management of systemic energy stores. Understanding how the actions of leptin on the CNS influence adipose tissues, and how...
There and Back Again: Leptin Actions in White Adipose Tissue
网页2020年8月21日 · Leptin is produced primarily by the adipocytes in white adipose tissue (WAT), where it plays important physiological roles both indirectly (primarily via the nervous system) and directly (in an autocrine action).
Direct and Indirect Effects of Leptin on Adipocyte Metabolism
网页This review discusses the effect of leptin on adipocyte metabolism. Because adipocytes express leptin receptors there is the potential for leptin to influence adipocyte metabolism directly. Adipocytes also are insulin responsive and receive sympathetic innervation, therefore leptin can also modify adipocyte metabolism indirectly.
A negative feedback loop between TET2 and leptin in adipocyte …
网页2024年4月1日 · Adipocyte Tet2 deficiency protects against high-fat diet-induced weight gain by reducing leptin levels and further improving leptin sensitivity in obese male mice. By...
Adipocyte iron regulates leptin and food intake - PubMed
网页Treatment of 3T3-L1 adipocytes with iron decreased leptin mRNA in a dose-dependent manner. We found that iron negatively regulates leptin transcription via cAMP-responsive element binding protein activation (CREB activation) and identified 2 potential CREB-binding sites in the mouse leptin promoter region.
Structural insights into the mechanism of leptin receptor ... - Nature
网页2023年3月31日 · Leptin is an adipocyte-derived protein hormone that promotes satiety and energy homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of hypothalamic neurons.
Adiponectin, Leptin, and Fatty Acids in the Maintenance of …
网页2016年5月10日 · Adiponectin, which increases as fat mass decreases, acts locally on the adipocyte to increase GLUT4-mediated glucose uptake while enhancing adipogenesis and adipocyte lipid storage. Fasting and leptin independently increase adipose tissue lipolysis, while fasting decreases leptin secretion.
Leptin Induces Proadipogenic and Proinflammatory Signaling in Adipocytes
网页2019年12月13日 · Here we show that leptin has direct effects in 3T3-L1 preadipocytes and adipocytes, as well as in ASCs, anticipating the commitment with the adipocyte lineage and adipogenesis. Continuous leptin supplementation had similar effects on the differentiation of primary mouse ASCs and the murine lineage of preadipocytes 3T3-L1, anticipating and ...
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