Aminoglycosides: An Overview - PMC - National Center for …
网页Aminoglycosides are potent, broad-spectrum antibiotics that act through inhibition of protein synthesis. The class has been a cornerstone of antibacterial chemotherapy since streptomycin (Fig. 1) was first isolated from Streptomyces griseus and …
Aminoglycoside - Wikipedia
网页Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside .
Structural and biochemical analyses of an aminoglycoside 2′-
网页2020年12月9日 · Aminoglycosides are broad-spectrum antibacterial compounds typically containing one aminocyclitol ring (the most common being 2-deoxystreptamine) linked to one or more amino sugars by glycosidic...
Aminoglycosides: From Antibiotics to Building Blocks for the …
网页2020年8月11日 · Aminoglycosides are a class of naturally occurring and semi synthetic antibiotics that have been used for a long time in fighting bacterial infections. Due to acquired antibiotic resistance and inherent toxicity, aminoglycosides have experienced a decrease in interest over time.
网页The aminoglycosides are a critical component of the current antibacterial arsenal. Their broad spectrum of activity, rapid bactericidal action, and favorable chemical and pharmacokinetic properties make them a clinically useful class of drugs across numerous infection types, in-cluding certain protozoal infections.
The Aminoglycosides: Streptomycin, Kanamycin, Gentamicin, Tobramycin ...
网页The aminoglycoside structure consists of two or more amino sugars bound by glycosidic linkage to a central hexose (aminocyclitol) nucleus. The highly polar, polycationic structure of the aminoglycosides contributes to their poor gastrointestinal absorption and inadequate penetration of the blood-brain barrier.
Aminoglycoside - an overview | ScienceDirect Topics
网页Introduction. The aminoglycosides are a group of antibiotics that act as bactericidal inhibitors of protein synthesis. Structurally, they are characterized by the presence of amino sugars attached to an aminocyclitol ring by glycosidic bonds. Moreover, as a group, they share certain pharmacokinetic properties.
Aminoglycosides: Perspectives on Mechanisms of Action and …
网页Aminoglycosides are multifunctional hydrophilic sugars that possess several amino and hydroxy functionalities. The amine moieties are mostly protonated in biological media; hence, these antibiotics can be considered polycationic species for the purpose of understanding their biological interactions.
Aminoglycosides: Mechanisms of Action and Resistance
网页2017年6月21日 · Aminoglycosides are classified based on their structure into four classes: (1) no deoxystreptamine (DOS) ring (e.g., streptomycin, which has a streptidine ring), (2) mono-substituted DOS (e.g., apramycin), (3) 4,5-disubstituted DOS (e.g., neomycin, ribostamycin), and (4) 4,6-disubstituted DOS (e.g., gentamicin, amikacin, tobramycin) [10, 12].
Aminoglycoside - an overview | ScienceDirect Topics
网页Aminoglycosides consist of two or more amino sugars joined in glycoside linkage to a hexose nucleus, usually in a central position. At physiologic pH, they are polycations with a high degree of polarity and water solubility and have no …
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