Aminoglycosides: An Overview - PMC - National Center for …
网页Aminoglycosides are potent, broad-spectrum antibiotics that act through inhibition of protein synthesis. The class has been a cornerstone of antibacterial chemotherapy since streptomycin (Fig. 1) was first isolated from Streptomyces griseus and …
Aminoglycoside - Wikipedia
网页Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside .
Aminoglycosides: From Antibiotics to Building Blocks for the …
网页2020年8月11日 · Aminoglycosides are a class of naturally occurring and semi synthetic antibiotics that have been used for a long time in fighting bacterial infections. Due to acquired antibiotic resistance and inherent toxicity, aminoglycosides have experienced a decrease in interest over time.
Structural and biochemical analyses of an aminoglycoside 2′-
网页2020年12月9日 · Aminoglycosides are broad-spectrum antibacterial compounds typically containing one aminocyclitol ring (the most common being 2-deoxystreptamine) linked to one or more amino sugars by glycosidic...
Aminoglycosides: Activity and Resistance | Antimicrobial Agents …
网页1999年4月1日 · The basic chemical structure required for both potency and the spectrum of antimicrobial activity of aminoglycosides is that of one or several aminated sugars joined in glycosidic linkages to a dibasic cyclitol.
Aminoglycoside - an overview | ScienceDirect Topics
网页Aminoglycosides are small hydrophilic and constitute one of the oldest class of antibiotics. Streptomycin was the first aminoglycoside discovered in 1914, and represents just one of a large class of antibiotics that share in common the general structure of two or more aminosugar joined by a glycosidic linkage to either hexose or aminoglycitol ...
Aminoglycosides - StatPearls - NCBI Bookshelf
网页2023年7月17日 · Mechanism of Action. Aminoglycosides have bactericidal activity in which they bind to the bacteria ribosomal 30S subunit. Specifically, they are believed to bind to the A-site (aminoacyl) on the 16S rRNA, a component of the ribosomal 30S subunit.
Aminoglycosides: Mechanisms of Action and Resistance
网页2017年6月21日 · Aminoglycosides are bactericidal antibiotics originally isolated from Actinomycetes species including Streptomyces and Micromonospora [9, 10]. The general mechanism of action of aminoglycosides is inhibition of protein synthesis by promotion of mistranslation and elimination of proofreading [11].
Aminoglycoside - an overview | ScienceDirect Topics
网页Introduction. The aminoglycosides are a group of antibiotics that act as bactericidal inhibitors of protein synthesis. Structurally, they are characterized by the presence of amino sugars attached to an aminocyclitol ring by glycosidic bonds. Moreover, as a group, they share certain pharmacokinetic properties.
Aminoglycosides - SpringerLink
网页2011年11月19日 · The aminoglycoside class began with the discovery of natural products that revolutionized the treatment of tuberculosis and other serious infections. Their broad spectrum of activity, broad utility across many indications, rapid …