Coxsackievirus B3 replication and pathogenesis - PubMed
网页Viruses such as coxsackievirus B3 (CVB3) are entirely host cell-dependent parasites. Indeed, they must cleverly exploit various compartments of host cells to complete their life cycle, and consequently launch disease. Evolution has equipped this pico-rna-virus, CVB3, to use different strategies, inc …
Coxsackievirus B3—Its Potential as an Oncolytic Virus
网页2021年4月21日 — Coxsackievirus B3 (CVB3) is a promising novel candidate with particularly valuable features. Its entry receptor, the coxsackievirus and adenovirus receptor (CAR), and heparan sulfate, which is used for cellular entry by some CVB3 variants, are highly expressed on various cancer types.
Exosomes mediate Coxsackievirus B3 transmission and expand the …
网页2023年1月12日 — CVB3 effectively infected virus receptor-negative cells and tissues. To characterize the infectivity of CVB3 in host cells, CVB3 virions were isolated from the supernatant of Caco-2-infected cell cultures via ultracentrifugation at 100,000×g .
Whole-genome analysis of coxsackievirus B3 reflects its genetic ...
网页2022年4月18日 — Coxsackievirus B3 (CVB3) has emerged as an active pathogen in myocarditis, aseptic meningitis, hand, foot, and mouth disease (HFMD), and pancreatitis, and is a heavy burden on public health. However, CVB3 has not been systematically analyzed with regard to whole-genome diversity and recombination.
Frontiers | Coxsackievirus B3 infects and disrupts human induced ...
网页2023年4月16日 — Coxsackievirus B3 (CVB3) is a significant human pathogen that is commonly found worldwide. CVB3 among other enteroviruses, are the leading causes of aseptic meningo-encephalitis which can be fatal especially in young children.
Attenuated strain of CVB3 with a mutation in the CAR ... - Nature
网页2021年6月14日 — In this report, we describe the creation and characterization of an avirulent strain of CVB3 as a live attenuated vaccine to prevent both myocarditis and pancreatitis induced by the wt CVB3...
The introduction of mutations in the wild type coxsackievirus B3 (CVB3 …
网页2022年10月3日 — Coxsackievirus B3 (CVB3) is a principal causative agent of viral myocarditis, meningitis and pancreatitis. There is no vaccine available for clinical use. It has been demonstrated that the primary molecular determinant of virulence phenotype is located in the 5’ UTR of the viral genome.
Coxsackievirus infection induces a non-canonical autophagy
网页2020年11月4日 — Coxsackievirus B3 (CVB3) is a single-stranded positive RNA virus that usurps cellular machinery, including the evolutionarily anti-viral autophagy pathway, for productive...
Transcriptomic analysis reveals that coxsackievirus B3 ... - Springer
网页2021年11月13日 — Coxsackievirus B3 (CVB3) is the most common cause of viral myocarditis in children and young people. Cytopathology induced directly by virus infection and replication and activation of the host immune response are two common causes of myocardial damage.
In Vitro Model Systems of Coxsackievirus B3-Induced Myocarditis ...
网页2021年9月14日 — Coxsackievirus B3 (CVB3) belongs to the enteroviruses, which are a well-known cause of acute and chronic myocarditis, primarily infecting cardiac myocytes. As primary human cardiomyocytes are difficult to obtain, viral myocarditis is quite frequently studied in vitro in different non-cardiac and cardiac-like cell lines.
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