CYP1A1 - Wikipedia
网页CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAH), for example, benzo [a]pyrene (BaP), by transforming it to an epoxide.
CYP1A1 Gene - GeneCards | CP1A1 Protein | CP1A1 Antibody
网页2024年8月5日 · CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP1A1 include Aryl Hydrocarbon Hydroxylase Inducibility and Phimosis. Among its related pathways are Metapathway biotransformation Phase I and II and Oxidation by cytochrome P450.
CYP1A1 cytochrome P450 family 1 subfamily A member 1
网页This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.
Cytochrome P450 CYP1A1: wider roles in cancer progression and ...
网页2009年6月16日 · CYP1A1 is one of the main cytochrome P450 enzymes, examined extensively for its capacity to activate compounds with carcinogenic properties. Continuous exposure to inhalation chemicals and environmental carcinogens is thought to increase the level of CYP1A1 expression in extrahepatic tissues, …
CYP1A1代谢的调节：从不良健康影响到化学预防和治疗选择
网页CYP1A1代谢的调节：从不良健康影响到化学预防和治疗选择. 人类细胞色素P450（CYP）1A1基因编码一种单加氧酶，该酶可代谢多种外源性和内源性底物。. CYP1A1因其苯并 [ a]的 氧化代谢而臭名昭著。. py和相关的多环芳烃，将这些化学物质转化为强效的人类致癌物 ...
Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes …
网页CYP1A1 is reported to be involved in the pathogenesis of lung cancer. CYP1A1 encodes aryl hydrocarbon hydroxylase (AHH) or benzo[α]pyrene (B[α]P) hydroxylase, which metabolizes PAHs in tobacco smoke (IARC 1987; Nebert et al. 2004). Patients with lung cancer exhibit enhanced expression of CYP1A1 in the bronchial mucosa.
Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes
网页Human cytochrome P450 enzymes (CYPs) play a critical role in various biological processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and CYP1B1, are induced by aryl hydrocarbon receptors (AhRs). The binding of ligands such as polycyclic aromatic hydrocarbons activates the AhR ….
AhR regulates the expression of human cytochrome P450 1A1 (CYP1A1…
网页The proximal promoter region [overlapping xenobiotic-responsive element (XRE) and GC box sequences] determined the basal expression of CYP1A1. In human hepatocellular carcinoma cells (HepG2) with aryl hydrocarbon receptor (AhR) or specificity protein 1 (Sp1) knockdown, we confirmed that AhR and Sp1 are involved in basal CYP1A1 expression.
Cytochrome P450 1A1 - an overview | ScienceDirect Topics
网页Cytochrome P450 1B1 (CYP1B1) is a heme-thiolate monooxygenase involved in NADPH-dependent phase I metabolism of a variety of xenobiotics.
New insights of CYP1A in endogenous metabolism: a focus on …
网页Cytochrome P450 1A (CYP1A), one of the major CYP subfamily in humans, not only metabolizes xenobiotics including clinical drugs and pollutants in the environment, but also mediates the biotransformation of important endogenous substances. In particular, some single nucleotide polymorphisms (SNPs) fo ….