CYP3A - Wikipedia
网页Cytochrome P450, family 3, subfamily A, also known as CYP3A, is a human gene locus. [2] [3] A homologous locus is found in mice. [4] The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes.
The Role of CYP3A in Health and Disease - PMC - National Center …
网页2022年10月24日 · CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43.
CYP3A - an overview | ScienceDirect Topics
网页CYP3A is the most abundant, clinically significant group of cytochrome P-450 isoenzymes. The CYP3A group is composed of four major isoenzymes: CYP3A3, CYP3A4, CYP3A5, and CYP3A7. CYP3A4 is the most common and is implicated in the majority of drug interactions.
CYP3A4抑制剂/诱导剂有哪些? - 知乎 - 知乎专栏
网页细胞色素p450体系是药物氧化代谢的核心体系，其中含量最丰富的是cyp3a亚家族，该酶系能催化50％的处方药（包括许多化疗药物）、环境致癌物、类固醇激素等的代谢。
Cytochrome P450 3A inhibitors and inducers - UpToDate
网页Cytochrome P450 3A (including 3A4) inhibitors and inducers. For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver enzymes, including CYP3A4, for elimination or activation.
CYP3A4 - Wikipedia
网页Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body.
CYP3A4 - 维基百科，自由的百科全书
网页蛋白转换. 人类的CYP3A4蛋白转换率变化范围很大。 对于 肝脏 部分的CYP3A4蛋白， 体内 方法估计该酶 生物半衰期 （英語： half-life）主要在70到140个小时； 体外 方法大概在26到79个小时。 [5] 肠道 CYP3A4蛋白的转换很可能类似于 肠上皮细胞 （英語： enterocyte）的更新率；一种非直接的方法，基于暴露于葡萄柚汁后的活性恢复，其测量结果在12到33个小时。 相互作用通路图. 點選圖中的基因，可連結到相對應的條目。 [註 1] [ [File: [ []] | { { …
CYP3A 的结构、功能、药物靶点以及临床应用等方面的研究进展
网页CYP3A 是一种重要的药物代谢酶,在药物临床应用中具有广泛的应用价值。 通过 CYP3A 抑制剂可以降低药物的代谢水平,延长药物的半衰期,增强药物的药效。 CYP3A 抑制剂在临床上主要用于治疗多种疾病,包括镇痛、镇静、抗抑郁、抗高血压等。 此外,CYP3A 抑制剂还可以用于预测药物相互作用,以及用于研究药物代谢动力学等。 随着研究的深入,CYP3A 抑制剂将在药物临床应用中发挥更大的作用。
CYP3A 基因家族在胃癌中的研究进展 - National Center for ...
网页2023年12月12日 · cyp3a家族的发现及组成. cyp3a家族作为cyp超家族中最丰富的亚族，由4个功能成员(cyp3a4、cyp3a5、cyp3a7、cyp3a43)和2个假基因成员(cyp3ap1和cyp3ap2)组成，其相应基因均位于7q21-q22上，但这些成员在组织分布和表达水平上有显著差异。
Structural Perspectives of the CYP3A Family and Their Small …
网页The CYP3A enzymes are critical for metabolizing both endogenous and exogenous compounds, and they have been reported to metabolize more than half of all currently prescribed drugs. 1 Members of the CYP3A family include CYP3A4, CYP3A5, CYP3A7, and CYP3A43. These enzymes catalyze various reactions and have exceptionally broad substrate specificity.