cAMP induces hypertrophy and alters DNA methylation in HL …
网页2015年9月15日 · Changes in expression of DNA methylation genes induced by elevated cAMP led to increased global DNA methylation in HL-1 cells. In contrast, inhibition of DNMT activity with 5-azacytidine treatment decreased global DNA methylation levels and blocked the increased expression of several HCM genes (Myh7, Gata4, Mef2c, Nfatc1, Myh7b, Tnni3, and Bnp ...
cAMP 诱导 HL-1 心肌细胞肥大并改变 DNA 甲基化。
网页2015年7月29日 · cAMP 升高诱导的 DNA 甲基化基因表达变化导致 HL-1 细胞中整体 DNA 甲基化增加。. 相比之下，用 5-氮杂胞苷处理抑制 DNMT 活性可降低整体 DNA 甲基化水平，并阻止 DBcAMP 处理观察到的几个 HCM 基因（Myh7、Gata4、Mef2c、Nfatc1、Myh7b、Tnni3 和 Bnp）表达的增加。. 这些结果 ...
cAMP signaling regulates DNA hydroxymethylation by …
网页2017年12月14日 · In their study Camarena et al. investigate the role of cAMP in DNA methylation. Using mainly imaging approaches the authors conclude that cAMP enhances the generation of 5-hydroxymethylcytosine (5hmC) (an indicator of DNA methylation/demethylation status) which results in significant changes in the programs of gene transcription of Schwann cells.
Oscillatory cAMP signaling rapidly alters H3K4 methylation
网页Here, we show that G protein–coupled receptors (GPCRs) alter H3K4 methylation via oscillatory intracellular cAMP. Activation of Gs-coupled receptors caused a rapid decrease of H3K4me3 by elevating cAMP, whereas stimulation of Gi-coupled receptors increased H3K4me3 by diminishing cAMP.
cAMP induces hypertrophy and alters DNA methylation in HL-1 ...
网页2015年9月15日 · DBcAMP alters the expression of DNA methylation enzymes and increases global DNA methylation levels in HL-1 cells. qPCR results revealed that DBcAMP treatment of HL-1 cells for 48 h significantly altered the mRNA expression of DNA methylation enzymes (A).
cAMP responsive element modulator α promotes effector T cells …
网页2023年7月12日 · Reduced methylation of the IFNG promoter in DN T cells allows for IFN-γ expression , and distinct DNA methylation patterns in CD8 + T cells allow distinguishing between patients with skin psoriasis, psoriatic arthritis and healthy individuals .
网页2015年3月2日 · decreased global DNA methylation levels and blocked the increased expression of several HCM genes (Myh7, Gata4, Mef2c, Nfatc1, Myh7b, Tnni3, and Bnp) observed with DBcAMP treatment. These results demonstrate that cAMP induces cardiomyocyte hypertrophy and altered HCM gene expression in vitro and that DNA methylation patterns mediate the ...
Cathelicidin antimicrobial peptide (CAMP) gene promoter methylation …
网页2021年4月23日 · Studies have shown that CAMP has defensive effects, such as regulating inflammation, inducing immune cells to injured or infected sites, binding and neutralizing lipopolysaccharide (LPS), promoting epithelialization, and repairing the damage [ ].
DNA methylation drives hematopoietic stem cell aging ... - Springer
网页1 天前 · Specifically, DNA methylation changes included global hypermethylation in non-coding regions and similar frequencies of hypo- and hyper-methylation at promoter regions, particularly affecting genes targeted by the PRC2 complex. ... cytoskeleton regulation, and the cAMP pathway (Fig. S8A). Specifically, we observed a strong hypermethylation in ...
cAMP Signaling Regulates DNA Demethylation by Augmenting …
网页2017年7月12日 · Here, we show that cAMP enhances the 26 generation of 5-hydroxymethylcytosine (5hmC) in multiple cell types. 5hmC is converted from 5-27 methylcytosine (5mC) by Tet methylcytosine dioxygenases ...
- 某些结果已被删除