Carboxypeptidase - Wikipedia
网页A carboxypeptidase (EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. This is in contrast to an aminopeptidases, which cleave peptide bonds at the N-terminus of proteins.
羧肽酶 - 百度百科
网页羧肽酶 (Carboxypeptidases, CPs)是一种 专一性地从肽链的C端逐个降解、释放 游离氨基酸 的一类肽链外切酶。. 羧肽酶A、B是一种 消化酶。. 可专一性地从 肽链 的C端开始逐个降解，释放出游离氨基酸的一类肽链外切酶。. 以酶原形式存在于生物体内。. 常用的有A、B …
Carboxypeptidase - an overview | ScienceDirect Topics
网页Carboxypeptidase A, EC 3.4.12.2, (pancreatic carboxypeptidase) is one of the longest known and most studied peptidases; its properties, structure and active site are known 1–6123456. It acts on many proteins and peptides but C-terminal proline and basic amino acids are not hydrolysed.
羧肽酶 - 维基百科，自由的百科全书
网页來自牛胰腺的 羧肽酶A （英语： Carboxypeptidase A）. 羧 suō 肽酶 （EC編號：3.4.16-3.4.18）屬於一種 蛋白 酶，可 水解 （裂解） 蛋白質 或 肽 的羧基端（C端）末的 肽鍵。. 過程與 氨肽酶 （英语：aminopeptidase） 相反，該氨基肽酶在蛋白質的N末端能夠切割肽鍵。. …
Carboxypeptidases in disease: Insights from peptidomic studies
网页Carboxypeptidases (CPs) perform many diverse physiological functions by removing C-terminal amino acids from proteins and peptides. Some CPs function in the degradation of proteins in the digestive tract while other enzymes play biosynthetic roles in the formation of neuropeptides and peptide hormones. Another set of CPs modify tubulin by ...
Carboxypeptidase - an overview | ScienceDirect Topics
网页Carboxypeptidases are regulatory peptide-processing enzymes that are secreted by human cells [1]. Carboxypeptidase G2, which is produced by Pseudomonas strain RS-16, hydrolyses the glutamate residue from methotrexate and other folate analogues [2] and rapidly hydrolyses methotrexate to the inactive metabolite DAMPA (4- [ [2,4-diamino-6 ...
Dissecting carboxypeptidase E: properties, functions and ...
网页2017年3月27日 · Carboxypeptidase E (CPE; EC 3.4.17.10), also known as enkephalin convertase and carboxypeptidase H, is required in the biosynthesis of most peptide hormones and neuropeptides and is localized in secretory granules of endocrine and neuroendocrine cells (1, 2).
Carboxypeptidases - SpringerLink
网页Carboxypeptidases catalyze the hydrolysis of peptide bonds at the C-terminus of peptides and proteins. This hydrolysis may be a step in the degradation of some substrate molecules or may result in the maturation of others.
Substrate Specificity and Structural Modeling of Human Carboxypeptidase …
网页2020年11月18日 · The five members that are catalytically active, named E, N, M, D, and Z, all show carboxypeptidase B-like substrate specificity, cleaving C-terminal basic residues . Carboxypeptidase E (CPE) primarily functions in the removal of C-terminal lysine and arginine residues from neuroendocrine peptide precursors in the secretory pathway .
Carboxyterminal Protein Processing in Health and Disease: Key …
网页2014年9月10日 · Carboxypeptidases are important mediators of cellular behavior. Through C-terminal truncations, they alter protein functionality and participate in proteome turnover. Similarly, carboxypeptidases shape the human peptidome by targeting neuroendocrine and vasoactive peptides, thereby regulating signaling pathways in the nervous and cardiovascular ...
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