Fenfluramine: a plethora of mechanisms? - PMC - National …
网页2023年5月12日 · Fenfluramine has a unique mechanism of action (MOA) among ASMs. Its primary MOA is currently described as dual-action sigma-1 receptor and serotonergic activity; however, other mechanisms may be involved. Here, we conduct an extensive review of the literature to identify all previously described mechanisms for fenfluramine.
Fenfluramine | C12H16F3N | CID 3337 - PubChem
网页Fenfluramine, a clinically effective appetite suppressant, releases serotonin from nerve terminals and inhibits its reuptake, and considerable evidence suggests that these effects mediate its anorectic activity. The D isomer of fenfluramine is particularly specific in affecting serotonin mechanisms and causing anorexia
Fenfluramine: A Review in Dravet and Lennox-Gastaut Syndromes
网页2023年6月15日 · Of note, both fenfluramine and norfenfluramine consist of a racemic mixture of two (d- and l-) isomers [6, 13, 20]; both l-isomers of the parent compound, as well as the d-isomer of the active metabolite, contributed to the efficacy of fenfluramine in the Zebrafish model of DS .
Species differences in the kinetics and metabolism of fenfluramine isomers
网页In rat and mouse d-fenfluramine had a longer half-life (T 1/2) and gave a larger area under the curve (AUC) than the l-isomer. These differences were consistent with stereoselective N-deethylation of l-fenfluramine. Thus, in both species the plasma and brain AUC of the l-metabolite were double that of the d-form.
Fenfluramine - Wikipedia
网页Fenfluramine, sold under the brand name Fintepla, is a serotonergic medication used for the treatment of seizures associated with Dravet syndrome and Lennox–Gastaut syndrome.
Fenfluramine: A Review of Pharmacology, Clinical Efficacy, and …
网页2022年8月2日 · Recently, the anti-obesity medication fenfluramine (FFA) has been successfully repurposed, and various regulatory agencies approved it for seizures associated with Dravet and Lennox–Gastaut syndromes. However, there is a limited in-depth critical review of FFA to facilitate its optimal use in a clinical context.
Fenfluramine modulates the anti-amnesic effects induced by …
网页2022年2月1日 · We report that Fenfluramine and particularly its dextrogyre isomer (+)-Fenfluramine, do act as S1R-positive modulators, while Norfenfluramine racemate and both dextrogyre and levogyre isomers rather act as S1R antagonists in vivo. Moreover, the steroidal tonus relying on drastic changes in DHEA, PREG, their sulfate esters, and progesterone may ...
Valvular Heart Disease Associated with Fenfluramine–Phentermine
网页1997年8月28日 · The d-isomer of fenfluramine, dexfenfluramine, also increases the risk of pulmonary hypertension, 6 particularly when patients receive high doses for more than three months.
Kinetics of fenfluramine isomers in the rat - Springer
网页The kinetics of fenfluramine isomers were studied in the rat following oral doses of racemic fenfluramine. The data, analyzed using an analogue computer, indicate that the d-fenfluramine is metabolised and excreted at a slower rate than the 1-isomer, resulting in higher plasma and brain concentrations.
Fenfluramine Hydrochloride | C12H17ClF3N | CID 91452
网页Description. Fenfluramine Hydrochloride is the hydrochloride salt of fenfluramine, an amphetamine derivative and a sympathomimetic stimulant with appetite-suppressant properties.