Glial cell line-derived neurotrophic factor - Wikipedia
网页Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. [5] GDNF is a small protein that potently promotes the survival of many types of neurons. [6] It signals through GFRα receptors, particularly GFRα1.
The GDNF family: Signalling, biological functions and ... - Nature
网页Members of the nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) families — comprising neurotrophins and GDNF-family ligands (GFLs), respectively — are crucial ...
胶质细胞源性神经营养因子 - 百度百科
网页胶质细胞源性神经营养因子 (glial cell derived neurotrophie factor，GDNF)是由Lin等 (1993)从鼠胶质细胞株B49的条件培养基中分离纯化获得的一种神经营养因子，且由此而命名。 以纯化的GDNF的氨基端序列制作探针，克隆得到大鼠和人的GDNF基因。 人GDNF前体蛋白为211个 氨基酸残基 (其中信号肽19个氨基酸)，加工处理后才形成分泌型的成熟蛋白，有134个氨基酸，是一个糖基化的二硫键连结的 同源二聚体 蛋白质，分子量为32~34kD，为 碱 …
GDNF, NGF and BDNF as therapeutic options for neurodegeneration
网页Glial cell-derived neurotrophic factor (GDNF), and the neurotrophin nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are important for the survival, maintenance and regeneration of specific neuronal populations in the adult brain.
GDNF Gene - GeneCards | GDNF Protein | GDNF Antibody
网页2024年8月6日 · GDNF (Glial Cell Derived Neurotrophic Factor) is a Protein Coding gene. Diseases associated with GDNF include Hirschsprung Disease 3 and Congenital Central Hypoventilation Syndrome. Among its related pathways are MAPK family signaling cascades and Kidney development.
GDNF, A Neuron-Derived Factor Upregulated in Glial Cells during …
网页2020年2月7日 · Glial cell line-derived neurotrophic factor (GDNF) has been isolated from the conditioned media of a rat glioma cell line on the basis of its trophic activity towards primary cultures of dopaminergic neurons [1].
GDNF and Parkinson’s Disease: Where Next? A Summary from a …
网页2020年7月28日 · What form should the GDNF be given in? •A gene therapy approach was favoured over protein infusions given the complexity of the neurosurgical intervention required for the former and the burden this places on the patients with Parkinson’s disease. •Consider using mammalian cell produced GDNF and NRTN proteins. Patient type
GDNF, A Neuron-Derived Factor Upregulated in Glial Cells ... - PubMed
网页2020年2月7日 · In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons, and, in some instances, it has also been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine fashion by forming a complex with the GDNF family receptor …
Therapeutic potential of GDNF in neuroinflammation: Targeted …
网页2023年9月1日 · GDNF exerts significant regulatory effects on neuroinflammation and has emerged as a therapeutic target for a wide range of drugs to mitigate neurological diseases. This review primarily focuses on elucidating the role of GDNF in neuroinflammation and exploring its therapeutic potential in treating neurological diseases.
GDNF to the rescue: GDNF delivery effects on motor neurons and …
网页2021年8月30日 · This review aims to discuss GDNF, Schwann cells’ role and GDNF in nerve repair mechanism, various exogenous GDNF delivery methods to treat PNIs, proper delivery challenges, and the potential role of electrical muscle stimulation and exercise as a complementary treatment following a PNI.
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