Activation of FXR by ganoderic acid A promotes remyelination in ...
网页ganoderic acid A. Multiple sclerosis (MS), as an inflammatory demyelinating disorder of central nervous system, is the leading cause of non-traumatic neurologic disability in young adults. The pathogenesis of MS remains unknown, however, a dysregulation of glia-neuroimmune signaling plays a key role during progressiv ….
Activation of FXR by ganoderic acid A promotes remyelination in ...
网页2021年3月1日 · Pharmacological and genetic ablation of farnesoid-X-receptor (FXR) abolished GAA-induced remyelination and restoration of motor deficiency in MS mice. Thus, GAA is a novel and potential therapeutic agent that can rescue MS neuroimmune imbalance and remyelination through an FXR receptor-dependent mechanism.
Chemical, biochemical, preclinical and clinical studies of Ganoderma ...
网页2018年4月24日 · Ganoderma lucidum, an edible medicinal mushroom known as “Lingzhi” in China and “Reishi or Manetake” in Japan 1 (Figure 1), has been used for promoting health and for extending life in China and in other East Asia countries for more than 2000 years.2 There are multiple species of Lingzhi, scientifically known to be within the Ganoderma ...
Ganoderma lucidum ethanol extract inhibits the inflammatory …
网页2013年1月15日 · Overproduction of these inflammatory mediators and cytokines causes severe neurodegenerative diseases, including AD, PD, cerebral ischemia, multiple sclerosis and trauma (20–22). Activated microglia are a major cellular source of pro-inflammatory and/or cytotoxic factors that cause neuronal damage in the CNS.
New efficacies of Ganoderma lucidum: Treatment of skin …
网页2020年10月7日 · Early treatment significantly reduces long-term disability in children with multiple sclerosis, new study finds
Ganoderma lucidum aqueous extract prevents hypobaric hypoxia …
网页2020年6月2日 · VRS anomalies are also common in dementia, focal brain dysfunction 29, multiple sclerosis 30 which further corroborates the observed memory loss. However, presence of GLAQ not only reduced the...
Frontiers | Long-Term Administration of Triterpenoids From Ganoderma …
网页2021年5月5日 · Ganoderma lucidum is rich in triterpenoids (Supplementary Table 1) and exerts pharmacological activities in the heart, liver, spleen, and brain (Supplementary Tables 2, 3). In this study, the effects of long-term administration of TGL were evaluated in 8-month normal aging mice and lasting for another 10 months, observing the effect of TGL on ...
Exploring the Potential Medicinal Benefits of Ganoderma lucidum: …
网页2023年4月3日 · 1. Introduction. There is a growing trend among consumers to seek out foods and dietary supplements that not only provide basic nutritional needs but also offer additional health benefits that may promote longevity and overall well-being.
Australeols A−F, neuroprotective meroterpenoids from Ganoderma australe
网页2019年4月1日 · Neuronal excitotoxicity is implicated in various neurodegenerative diseases such as Alzheimer's disease, multiple sclerosis, ischemic stroke as well as Parkinson's disease. Increasing evidences showed that glutamate induced excitotoxicity is pivotal in neuronal damage during cerebral ischemia [[26], [27], [28], [29], [30], [31]].
Therapeutic applications of mushrooms and their biomolecules …
网页2021年5月1日 · Ganoderma lucidum (GI) (Lingzhi mushroom) serves a neuronal protective function against NDs [63]. The GI aqueous extract at the concentration of 500 mg/mL recovers the synaptic dysfunction via inhibiting the mushroom spine shape against Aβ based synaptotoxicity in rat cortical neurons via JNK and P39 kinase pathway [64].
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