常见致病菌糖基转移酶的结构与功能 - 中国生物化学 ...
网页糖基转移酶 (glycosyltransferases,GTs)将糖基从活化的供体转移到糖、脂、蛋白质和核酸等受体,其参与的蛋白质糖基化是最重要的翻译后修饰 (post-translational modifications,PTMs)之一。. 近年来越来越多的研究证明,糖基转移酶与致病菌毒力密切相关,在致病菌的黏附、免疫 ...
Glycosyltransferases: structures, functions, and mechanisms
网页Glycosyltransferases catalyze glycosidic bond formation using sugar donors containing a nucleoside phosphate or a lipid phosphate leaving group. Only two structural folds, GT-A and GT-B, have been identified for the nucleotide sugar-dependent enzymes, but other folds are now appearing for the solubl ….
网页摘 要：糖基化是一种十分重要且独特的天然产物结构修饰方式，该修饰由天然产物糖基转移酶 (natural product glycosyltransferases, NP-GTs) 催化完成，可以改变底物的理化性质或生物学活性。
糖基转移酶 - 百度百科
网页糖基转移酶在生物体内催化活化的糖连接到不同的受体分子，如蛋白、核酸、寡糖、脂和小分子上，糖基化的产物具有很多生物学功能。 葡萄糖基转移酶是在酶反应中只转移葡萄糖基的酶（Glu-酶），葡萄糖苷转移酶是转移时连葡萄糖的糖苷键一起转移着的酶。
Glycosyltransferases and Glycan-Processing Enzymes - Essentials …
网页Glycosyltransferases and Glycan-Processing Enzymes. Glycosyltransferases and glycosidases are responsible for the assembly, processing, and turnover of glycans. In addition, there are a number of transferases that modify glycans by the addition of acetyl, methyl, phosphate, sulfate, and other groups.
Structures and mechanisms of glycosyltransferases
网页2005年7月21日 · Glycosyltransferases (GTs) catalyze the transfer of a sugar moiety from an activated donor sugar onto saccharide and nonsaccharide acceptors. A sequence-based classification spreads GTs in many families thus reflecting the variety of molecules that can be used as acceptors.
网页糖基转移酶可以调节神经细胞表面多种蛋白质及 脂质的糖基化，参与神经系统的发生及多种疾病发病过程的调控。 对糖基转移酶在神经系统发育和疾病中
糖基转移酶：结构，功能和机制。,Annual Review of Biochemistry
网页转化糖基转移酶利用涉及酶基础催化剂的直接置换的s（n）2-样机制。 通常通过配位的二价阳离子促进GT-A折叠酶中的基团离开，而GT-B折叠酶则使用带正电荷的侧链和/或羟基和螺旋偶极子。
Glycosyltransferases: mechanisms and applications in natural …
网页2015年9月2日 · In order to understand the full potential of Gts, the chemical and structural glycosylation mechanisms are systematically summarized in this review, including some new outlooks in inverting/retaining mechanisms and the overview of GT-C superfamily proteins as a novel Gt fold.
Bacterial Glycosyltransferases: Challenges and Opportunities of a ...
网页2016年2月18日 · Glycosyltransferases (GTs) represent a subclass of enzymes that catalyze the synthesis of glycosidic linkages by the transfer of a sugar residue from a donor substrate to an acceptor. Acceptor substrates are mono-, di-, or oligo- carbohydrates, as well as proteins, lipids, DNA, and numerous other small molecules ( Lairson et al., 2008 ).
跳至内容