Insulin-like growth factor 2 - Wikipedia
网页Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized neutral peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like and mitogenic activities.
IGF2 Gene - GeneCards | IGF2 Protein | IGF2 Antibody
网页2024年8月6日 · IGF2 (Insulin Like Growth Factor 2) is a Protein Coding gene. Diseases associated with IGF2 include Silver-Russell Syndrome 3 and Silver-Russell Syndrome 1. Among its related pathways are Apoptotic Pathways in …
IGF2: epigenetic regulation and role in development and disease
网页Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of all growth factors characterized to date. Its gene is imprinted--only one allele is active, depending on parental origin--and this pattern of expression is maintained epigenetically in almost all tissues.
IGF2 gene - MedlinePlus
网页The IGF2 gene provides instructions for making a protein called insulin-like growth factor 2. This protein plays an essential role in growth and development before birth. Studies suggest that insulin-like growth factor 2 promotes the growth and division (proliferation) of cells in many different tissues.
IGF2 : Development, Genetic and Epigenetic Abnormalities
网页2022年6月10日 · Insulin-like growth factor two (IGF-II) is a key protein regulating growth, particularly during normal fetal development, but it is also often dysregulated during tumorigenesis [1, 2, 3]. In this review, we focus on the role of IGF-II in physiological functions and its regulation by cis or trans genetic factors.
Activation of the insulin receptor by insulin-like growth factor 2
网页2024年3月23日 · IGF2 exhibits a relatively weak binding to IR site-2 compared to insulin, making it less potent in promoting full IR activation. Cell-based experiments validated the functional importance of...
Understanding IGF-II Action through Insights into Receptor …
网页2020年10月12日 · The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and is especially important during fetal growth and development.
The Neglected Insulin: IGF-II, a Metabolic Regulator with …
网页2019年10月6日 · Insulin-like growth factor-II (IGF-II) is one of the most abundant growth factors and, by far, the most abundant peptide with insulin-activity in the body. Some 21 years ago, I wrote an editorial commenting that, despite this, remarkably little was known regarding the physiology of IGF-II [1].
Insulin-Like Growth Factor 2 - an overview - ScienceDirect
网页The insulin-like growth factors, IGF-I and IGF-II, are 7.5-kDa single-chain protein homologues of insulin that promote cell growth, survival, migration and differentiation in vitro, and have insulin-like activity (Jones and Clemmons 1995, Stewart and Rotwein 1996).
胰島素樣生長因子 - 维基百科，自由的百科全书
网页類胰島素生長因子 （insulin-like growth factors，簡稱 IGFs）為一種與 胰島素 序列高度相似的 蛋白质 激素。. 可以調控生理環境的 複雜系 （英语：complex system），該系統由兩種 細胞表面受體 （IGF1R及IGF2R）以及兩種 配體 （IGF-1 、 IGF-2 （英语：Insulin-like growth factor 2 ...