咪唑 - 维基百科，自由的百科全书
网页咪唑环结构在生物分子中广泛存在，例如组氨酸和对应的荷尔蒙 组胺。 很多药物也包含有咪唑环，例如 硝基咪唑 和咪唑类 抗真菌药物 。 [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ]
Imidazole - Wikipedia
网页Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole. For comparison, another group of azoles is the triazoles, which includes fluconazole, itraconazole, and voriconazole.
Imidazole: Having Versatile Biological Activities - Verma - 2013 ...
网页2013年10月31日 — Imidazoles are well-known heterocyclic compounds which are common and have an important feature of a variety of medicinal agents. On the basis of various literature surveys, imidazole derivatives show various pharmacological activities: (i) antibacterial activity; (ii) anticancer activity; (iii) antitubercular activity; (iv) antifungal; (v)
咪唑 - 维基百科，自由的百科全书
网页组氨酸 脱羧反应 咪唑一个用途是在 金属螯合亲和层析 (IMAC)中用于 His标签蛋白 的纯化。 标签蛋白与 层析柱 表面珠孔内的 镍 离子介质发生结合，过量的咪唑通过层析柱，将与镍配位的标签蛋白洗脱下来，得到高纯度的目标蛋白。
Synthesis and therapeutic potential of imidazole containing …
网页2021年2月18日 — Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. It is also known as 1, 3-diazole. It contains two nitrogen atoms, in which one nitrogen bear a hydrogen atom, and the other is called pyrrole type nitrogen.
Recent pharmacological insights about imidazole hybrids: a ...
网页2024年5月13日 — In this review, we evaluated the biological activities of hybrid molecules incorporating imidazoles—a cornerstone in medicinal chemistry known for their broad pharmacological spectrum, attributed to the chemical characteristics of their nitrogen atoms.
Imidazoles as Potential Anticancer Agents: An Update on Recent …
网页2021年7月11日 — 1-Substituted-2-aryl imidazoles were synthesized by Li et al. as potential tubulin-targeted anticancer agents . The target compounds were tested on MDA-MB-468, MDA-MB-231, T47D, HCT-15, HT29, and HeLa cancer cell lines along with a normal human umbilical vein endothelial cell line (HUVEC).
Imidazole and Derivatives Drugs Synthesis: A Review
网页For a century and a half, purine, histamine, and other natural compounds all contained the imidazole ring. A number of imidazole drugs have been prepared and marketed for the treatment of various diseases. In view of this, we herein report a detailed account of synthetic procedures for various imidazole drugs.
Imidazole: Synthesis, Functionalization and Physicochemical …
网页2023年1月13日 — Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline. The current literature provides much information about the synthesis, functionalization, physicochemical characteristics and biological role of imidazole.
Imidazole Compounds: Synthesis, Characterization and Application …
网页2022年1月10日 — Imidazole is a five-membered heterocyclic ring containing three carbon atoms, two nitrogen atoms, and two double bonds. Among two nitrogen atoms, one of which carries with a hydrogen atom is a pyrrole-type nitrogen atom, another is a …