Liensinine (莲心碱) - 仅供科研 | 线粒体自噬抑制剂 | MCE
网页Liensinine, a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn, has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc.
Liensinine, a Novel and Food-Derived Compound, Exerts Potent ...
网页2024年2月21日 · In this study, we performed virtual screening to target the presumed inhibitor-binding pocket and identified a highly potent Kv10.1 inhibitor, liensinine (Lien), which can inhibit the channel in a dose-dependent way with an IC 50 of 0.24 ± 0.07 μM. Combining molecular dynamics simulations with mutagenesis experiments, our …
Liensinine, a alkaloid from lotus plumule, mitigates …
网页The present study aims to investigate the role of liensinine in life-threatened sepsis-associated encephalopathy (SAE) mice and the underlying mechanism. Here, seventy-two mice were divided into six groups, including the control group, SAE group, liensinine-treated group, and three doses of liensini …
Liensinine pretreatment reduces inflammation, oxidative stress ...
网页We first found that liensinine significantly reduced kidney injury in sepsis mice, while suppressing excessive inflammatory responses, restoring renal oxidative stress-related biomarkers, reducing increased apoptosis in TUNEL-positive cells and excessive autophagy, and that this process was accompanied by an increase in JNK/ p38-ATF 2 axis.
网页Liensinine (1) is a plant-derived isoquinoline-type alka-loid from the seed embryo of Nelumbo nucifera Gaertn., Nelumbonaceae, or lotus seed. Studies have demonstrated that liensinine had a therapeutic potential to inhibit cancer cell development (Kang et al. 2017; Shen et al. 2019; Jia et al. 2022) and inhibit brosis and inammation (Xiao et al.
Liensinine and neferine exert neuroprotective effects via the …
网页2023年10月27日 · Results: We found that liensinine and neferine could significantly improve the viability and reduce ROS levels in APP695swe SH-SY5Y cells, inhibit β-amyloid and tau-induced toxicity, and enhance stress resistance in nematodes.
Role of liensinine in sensitivity of activated macrophages to ...
网页2023年6月23日 · We used liensinine (Lie) as a drug of choice after screening a library of small-molecule monomers with 1488 compounds from traditional Chinese remedies. In ALI, we evaluated the potential...
Liensinine and Nuciferine, Bioactive Components of
网页2017年12月3日 · Liensinine, a bisbenzylisoquinoline alkaloid, has been reported to inhibit autophagy and to increase apoptosis in breast cancer cells cotreated with various chemotherapeutic agents .
Liensinine improves AngII-induced vascular remodeling via …
网页2023年12月5日 · Liensinine is an effective alkaloid for the treatment of hypertensive vascular injury. The inhibition of MAPK/TGF-β1/Smad2/3 signaling pathway axis is a key mechanism of Lien treating hypertensive vascular injury.
Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in …
网页2022年7月1日 · Liensinine is a bioactive component of Plumula Nelumbinis extracted from the green embryo of the mature seeds of Nelumbonaceae and exhibits therapeutic functions and noteworthy anti-tumor effects in recent studies.