Melanocortin 1 receptor - Wikipedia
网页The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different ...
Melanocortin 1 Receptor: Structure, Function, and Regulation
网页2016年5月30日 · The melanocortin 1 receptor (MC1R) is a melanocytic G s protein coupled receptor that regulates skin pigmentation, UV responses, and melanoma risk. It is a highly polymorphic gene, and loss of function correlates with a fair, UV-sensitive, and melanoma-prone phenotype due to defective epidermal …
Melanocortin-1 receptor mutations and pigmentation: Insights …
网页2022年1月1日 · The melanocortin-1 receptor (MC1R) is a G protein-coupled receptor expressed in cutaneous and hair follicle melanocytes, and plays a central role in coat color determination in vertebrates. Numerous MC1R variants have …
MC1R, the cAMP pathway and the response to solar UV: …
网页The melanocortin 1 receptor (MC1R) is a G protein-coupled receptor crucial for the regulation of melanocyte proliferation and function. Upon binding melanocortins, MC1R activates several signaling cascades, notably the cAMP pathway leading to synthesis of photoprotective eumelanin.
MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB
网页2023年9月7日 · Melanocortin 1 receptor (MC1R) is a G-protein-coupled receptor (GPCR) that regulates skin pigmentation, cell proliferation, and apoptosis 1. The binding of...
Activation of melanocortin-1 receptor signaling in melanoma cells ...
网页2023年9月15日 · Depletion of MC1R activates antitumor T cell response in B16F10 melanoma. To identify the cellular mechanisms by which MC1R drives immune evasion, we used flow cytometry to quantify infiltrated...
Melanocortin-1 receptor mutations and pigmentation: Insights
网页The melanocortin-1 receptor (MC1R) is a G protein-coupled receptor expressed in cutaneous and hair follicle melanocytes, and plays a central role in coat color determination in vertebrates. Numerous MC1R variants have been identified in …
The melanocortin 1 receptor (MC1R): more than just red hair
网页Loss-of-function mutations at the MC1R are associated with a switch from eumelanin to phaeomelanin production, resulting in a red or yellow coat colour. Activating mutations, … The melanocortin 1 receptor, a seven pass transmembrane G protein coupled receptor, is a key control point in melanogenesis.
Palmitoylation-dependent activation of MC1R prevents ... - Nature
网页2017年9月6日 · Here we demonstrate a potential MC1R-targeted intervention strategy in mice to rescue loss-of-function MC1R in MC1R RHC variants for therapeutic benefit by activating MC1R protein...
MC1R Functions, Expression, and Implications for Targeted Therapy
网页2022年2月1日 · The G protein-coupled MC1R is expressed in melanocytes and has a pivotal role in human skin pigmentation, with reduced function in human genetic variants exhibiting a red hair phenotype and increased melanoma predisposition. Beyond its role in pigmentation, MC1R is increasingly recognized as promoting UV …