Nephrotoxicity - Wikipedia
网页Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way.
Nephrotoxicity: Role and significance of renal biomarkers in …
网页Different mechanisms lead to nephrotoxicity, including renal tubular toxicity, inflammation, glomerular damage, crystal nephropathy, and thrombotic microangiopathy. The traditional markers of nephrotoxicity and renal dysfunction are blood urea and serum creatinine which are regarded as low sensitive in the detection of early renal damage.
Nephrotoxic Medications - StatPearls - NCBI Bookshelf
网页2023年6月21日 · Describe the most common drug classes that can contribute to an increased incidence of renal damage. Identify the main drugs that are more likely to be nephrotoxic and how clinicians should proceed with treatment. Outline some renal pathologies that can become a result of nephrotoxic drug administration.
The 6R’s of drug induced nephrotoxicity - BMC Nephrology
网页2017年4月3日 · Drug-induced nephrotoxicity is increasingly recognized as a significant contributor to kidney disease including acute kidney injury (AKI) and chronic kidney disease (CKD). Nephrotoxicity has a wide spectrum, reflecting damage to different nephron segments based upon individual drug mechanisms.
The Mechanism of Drug Nephrotoxicity and the Methods for …
网页2021年6月6日 · Drug-induced nephrotoxicity develops according to one of the three mechanisms: (1) proximal tubular injury and acute tubular necrosis (ATN) (a dose-dependent mechanism), where the cause is related to apical contact with drugs or their metabolites, the transport of drugs and their metabolites from the apical surface, and the secretion of drugs ...
Nephrotoxicity and Renal Pathophysiology: A Contemporary …
网页2018年6月25日 · Nephrotoxicity can be defined as the adverse effect of substances on renal function (Perazella, 2009). These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of abuse such as cocaine.
A Review on Drug-Induced Nephrotoxicity: Pathophysiological
网页This review summarizes pathophysiological mechanisms of drug-induced nephrotoxicity, classes of nephrotoxic drugs, management, prevention, and diagnosis in clinics. Finally, it also highlights some of the recent advancements in mathematical M&S approaches that could be used to better understand and predict drug-induced nephrotoxicity.
Nephrotoxicity and Renal Pathophysiology: A Contemporary
网页2018年8月1日 · This review summarizes the current state of the field of nephrotoxicity. It emphasizes integrating our understanding of nephrotoxicity with pathological-induced renal failure. Such approaches are needed to address major questions in the field, which include the diagnosis, prognosis and treatment of both acute and chronic renal failure, and the ...
Drug-induced nephrotoxicity - PubMed
网页2020年1月13日 · Nephrotoxicity can be defined as any renal injury caused directly or indirectly by medications, with acute renal failure, tubulopathies, and glomerulopathies as commo …
What is Nephrotoxicity? - News-Medical.net
网页2022年6月1日 · Nephrotoxicity is defined as the rapid deterioration in kidney function as a result of medications and chemicals. Nephrotoxicity can also be defined as an adverse event caused by...
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