OPCML Gene - GeneCards | OPCM Protein | OPCM Antibody
网页2024年8月6日 · OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like) is a Protein Coding gene. Diseases associated with OPCML include Ovarian Cancer and Autism Spectrum Disorder. Among its related pathways are Metabolism of proteins and Post-translational modification: synthesis of GPI-anchored proteins.
OPCML: A Promising Biomarker and Therapeutic Avenue
网页Opioid-binding protein/cell adhesion molecule (OPCML) is expressed in many tissues and localizes to the plasma membrane. It is a putative tumor suppressor that acts on receptor tyrosine kinases (RTKs), influencing cell cycle arrest, apoptosis, and migration. Its expression is silenced epigenetically …
Emerging roles for the GPI-anchored tumor suppressor OPCML in …
网页2020年6月29日 · OPCML is a highly conserved glycosyl phosphatidylinositol (GPI)-anchored protein belonging to the IgLON family of cell adhesion molecules. OPCML functions as a tumor suppressor...
Inactivating mutations and X-ray crystal structure of the tumor ...
网页2019年7月17日 · Opioid-binding protein cell-adhesion molecule like (OPCML) is a glycosylphosphatidylinositol (GPI)-anchored protein that localizes to the outer leaflet of the...
Expression and promoter methylation status of OPCML and its …
网页Methylation of the OPCML promoter was detected in all breast cancer cell lines and primary tumors but was not detected in surgical margin tissues and normal breast tissues. Furthermore, functional assays showed that ectopic OPCML expression could inhibit breast tumor cell proliferation in vivo and in vitro and further suppresses tumor cell ...
The OPCML Tumor Suppressor Functions as a Cell Surface …
网页2012年2月12日 · OPCML is a nontransmembrane, external lipid leaflet-anchored protein with no direct route to affect proliferative intracellular signaling. We therefore hypothesized that it may mediate its tumor suppressor properties via transmembrane signaling proteins and analyzed the effect of RTK growth factor stimulation on OPCML gene expression.
OPCML Methylation and the Risk of Ovarian Cancer: A Meta and ...
网页2021年3月11日 · Opioid binding protein cell adhesion molecule-like (OPCML) gene at 11q25 is a glycosyl-phosphatidylinositol (GPI)-anchored cell adhesion-like molecule and belongs to the IgLON family (Wu and Sood, 2012). OPCML demonstrates tumor-suppressor function in epithelial ovarian cancer both in vitro and in vivo (Sellar et al., 2003). Subsequently, the ...
OPCML Is a Broad Tumor Suppressor for Multiple Carcinomas and …
网页2008年8月20日 · Identification of tumor suppressor genes (TSGs) silenced by CpG methylation uncovers the molecular mechanism of tumorigenesis and potential tumor biomarkers. Loss of heterozygosity at 11q25 is common in multiple tumors including nasopharyngeal carcinoma (NPC). OPCML, located at 11q25, is one of the downregulated genes we identified through ...
OPCML - Wikipedia
网页Opioid-binding protein/cell adhesion molecule is a protein that in humans is encoded by the OPCML gene. This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the cell membrane and may have an accessory role in opioid receptor function.
网页OPCML is a highly conserved glycosyl phosphatidylinositol (GPI)-anchored protein belonging to the IgLON family of cell adhesion molecules. OPCML functions as a tumor...