冬凌草甲素 - 百度百科
网页冬凌草甲素，外文名称为Oridonin，是从唇形科 (Iabtea) 香茶菜属 (Rabdosia)植物中分离出来的一种有 生物活性 的天然物质。. 其主要成分为贝壳杉烷型四环二萜类天然有机化合物 (ent-kau-renediterpenoid)，为无色棱柱状结晶，味道极苦，难溶于水，可溶于乙醚、甲醇 ...
Oridonin: A Review of Its Pharmacology, Pharmacokinetics and …
网页2021年7月5日 · The purpose of this review focuses on providing the latest and comprehensive information on the pharmacology, pharmacokinetics and toxicity of oridonin, to excavate the therapeutic potential and explore promising ways to balance toxicity and efficacy of this natural compound.
Oridonin is a covalent NLRP3 inhibitor with strong anti ... - Nature
网页2018年6月29日 · Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown.
Oridonin | C20H28O6 | CID 5321010 - PubChem
网页Oridonin is an organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an apoptosis inducer, an anti-asthmatic agent, a plant metabolite and an antibacterial agent.
Oridonin is a covalent NLRP3 inhibitor with strong anti ... - PubMed
网页2018年6月29日 · Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases.
Oridonin from Rabdosia rubescens: An emerging potential in …
网页In this regard, oridonin (ORI), an ent-kaurane diterpenoid, naturally found in the leaves of Rabdosia rubescens species, has been found to have antitumor, antiangiogenesis, antiasthmatic, antiinflammatory, and apoptosis induction properties. Extensive research has been performed on ORI to find various mechanisms involved in its anticancer ...
Oridonin and its derivatives for cancer treatment and overcoming ...
网页2020年7月5日 · The natural product (NP) oridonin has been extensively studied for its anti-cancer efficacy. More recently, oridonin has been shown to overcome drug resistance through multiple mechanisms, with yet-to-be-defined bona fide targets.
Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity
网页2021年7月5日 · Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon rubescens (Hemsl.) H.Hara, is widely present in numerous Chinese medicine preparations. The purpose of this review focuses on providing the latest and comprehensive information on the pharmacology, pharmacokinetics and toxicity of oridonin, to excavate the ...
Oridonin: A Review of Its Pharmacology, Pharmacokinetics and …
网页2021年7月4日 · Oridonin produced a conspicuous effect of neuroprotective in PC12 and N2a cells by rescuing IR, reducing the autophagosome formation and synaptic loss and ameliorating cognitive dysfunction, halting IR-induced synaptic deficits (Wen et al., 2020).
Recent advances in oridonin derivatives with anticancer activity
网页2023年2月9日 · Oridonin is an ent-kaurane tetracyclic diterpenoid isolated from Rabdosia rubescens and has been a target of extensive research over the last few years. It displays a broad range of biological effects including neuroprotective, anti-inflammatory, and anticancer activity against a variety of tumor cells.