细胞衰老和老化概述 | Cell Signaling Technology
网页细胞周期停滞通过 p53/p21 CIP1 或 p16 INK4A /磷酸化-Rb 肿瘤抑制基因通路的激活所介导。有趣的是，在不同类型的癌症中常发现通路组分中的突变。 有趣的是，在不同类型的癌症中常发现通路组分中的突变。
国际共识的细胞衰老标志物及检测方法，你get到了吗？ - 知乎
网页细胞周期相关因子p16、p21、p53、RB、Ki67。RB和p53蛋白对于衰老细胞周期停滞至关重要。CDK2的抑制因子p21和CDK4/6的抑制因子p16会在衰老细胞中发生积累，这种积累促使RB家族蛋白持续活化，抑制E2F的反式激活，从而导致无法逆转的细胞周期停滞。
Role of p53 in the Regulation of Cellular Senescence
网页2020年3月8日 · Various internal or external stress factors trigger the DNA-damage response (DDR) pathway, which in turn activates the p53 and/or the p16 INK4A pathways. p16 INK4A inactivates Cdk4/6, results in accumulation of phosphorylated pRb, stops the regulation of E2F transcription factors, and drives cell cycle arrest or senescence.
Senescence and aging: the critical roles of p53 | Oncogene - Nature
网页2013年2月18日 · p53 functions as a transcription factor involved in cell-cycle control, DNA repair, apoptosis and cellular stress responses. However, besides inducing cell growth arrest and apoptosis, p53...
衰老信号 | Cell Signaling Technology
网页这些刺激信号通过多种细胞内途径进行——包括 DDR 组件 ATR、ATM 和 p53——聚合了周期蛋白依赖性激酶抑制剂 (CDKI) 的激活——p16、 p21 和 p27，并导致视网膜母细胞瘤蛋白 (RB) 的超磷酸化，并且最终退出细胞周期。. 尽管衰老细胞不再增殖，但它们仍具有代谢活性 ...
Expression of p16 and p53 in non-small-cell lung cancer ...
网页p16 and p53 are frequently altered intracellular pathways in cancers. We investigated the aberrant expression of p16 and its relationship with p53 and HPV status in primary non-small-cell lung carcinoma. Patients & methods: Lung tumor tissue microarray (n = 163), immunohistochemical study of p16 and p53, and HPV in-situ hybridization were analyzed.
p53 and p16 INK4A independent induction of senescence by
网页2011年9月13日 · Senescence growth arrest usually depends on the activation of the CDK inhibitors (p21 CIP1 and p16 INK4A), components of the tumour-suppressor pathways governed by the p53 and retinoblastoma...
Reversal of human cellular senescence: roles of the p53 and p16 ...
网页2003年8月15日 · Our results indicate that the senescence response to telomere dysfunction is reversible and is maintained primarily by p53. However, p16 provides a dominant second barrier to the unlimited growth of human cells.
The Role of p53/p21/p16 in DNA-Damage Signaling and DNA Repair
网页p53/p21/p16 tumor suppressors in control of the G1/S cell–cycle checkpoint. The tumor-suppressor proteins p53, p21, and p16 are major regulators of the G1/S cell–cycle checkpoint. Upon p53 stabilization, the transcription of p21 is induced, subsequently resulting in the inhibition of CDK4/6–cyclin D and CDK2–cyclin E complexes by p21.
p53 induces senescence through Lamin A/C stabilization ... - Nature
网页2019年2月6日 · Here we show that p53 induces p16 through Lamin A/C stabilization via direct interaction. Stabilized Lamin A/C promotes degradation of BMI-1 and MEL-18 (Polycomb repressor complex 1, PRC1),...