Polysialic acid - Wikipedia
网页Polysialic acid is a polyanionic polymer of sialic acid residues that modifies neural cell adhesion molecules and other proteins. Learn about its structure, synthesis, detection methods, and roles in membrane, neuron signaling, immune system and more.
The polyfunctional polysialic acid: A structural view
网页2021年9月1日 · Polysialic acid (polySia) is a homopolymer of α2,8-linked sialic acid residues that modifies a few proteins in vertebrates. Learn about the structure-function relationships of polySia and its interaction partners in humans, and how the degree of polymerisation influences its regulatory effects.
Polysialic acid in the plasticity of the developing and adult ...
网页Polysialic acid (PSA) is a cell-surface glycan that has an enormous hydrated volume that serves to modulate the distance between cells and, thereby, the strength of their interaction. PSA...
The different prognostic significance of polysialic acid and CD56 ...
网页2022年7月2日 · Through immunohistological analysis of breast cancer patient tumors, we have discovered the expression of an atypical glycan—polysialic acid (polySia)—in breast cancer.
Polysialic Acid in the Immune System - PMC - National Center for ...
网页2022年2月11日 · Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent biophysical characteristics that when expressed drastically influences the interaction properties of cells.
Sialic acid and biology of life: An introduction - PMC
网页2020年1月17日 · Sialic acids or N -acetylneuraminic acids (Neu5Ac) are a diverse group of 9‑carbon carboxylated monosaccharides synthesized in animals, present at the outermost end of N -linked and O -linked carbohydrate chains and in lipid-associated glycoconjugates (Fig. 1 , 1–6) and lack in plants [6].
The polyfunctional polysialic acid: A structural view - PubMed
网页Polysialic acid (polySia), a homopolymer of α2,8-linked sialic acid residues, modifies a small number of proteins and has central functions in vertebrate signalling. Here, we review the regulatory functions of polySia in signalling processes and the immune system of adult humans, as well as function ….
Polysialylation and disease - PubMed
网页Polysialic acid (polySia, PSA) is a unique constituent of the glycocalyx on the surface of bacterial and vertebrate cells. In vertebrates, its biosynthesis is highly regulated, not only in quantity and quality, but also in time and location, which allows polySia to be involved in various important biological phenomena.
Polysialic acid sustains cancer cell survival and migratory
网页2016年9月9日 · Polysialic acid (polySia) is a unique carbohydrate polymer expressed on the surface of NCAM (neuronal cell adhesion molecule) in a number of cancers where it modulates cell-cell and cell-matrix...
Bioproduction, purification, and application of polysialic acid
网页2018年9月22日 · Polysialic acid (PSA) is a negatively charged linear homopolymer linked by N-acetylneuraminic acid and widely present in vertebrates and some pathogens. PSA, commonly found on cell surfaces as glycoproteins and glycolipids, plays important roles in intercellular adhesion, cell migration, and formation and remodeling of …