General Principles of Preclinical Study Design - PMC
网页2020年1月1日 · In this chapter, we will focus on hypothesis testing type of preclinical studies and explain general concepts and principles in relation to the design of in vivo experiments, provide definitions of experimental biases and how to avoid them, and discuss major sources contributing to experimental biases and how to mitigate these sources.
General Principles of Preclinical Study Design | SpringerLink
网页2019年11月10日 · In this chapter, we will focus on hypothesis testing type of preclinical studies and explain general concepts and principles in relation to the design of in vivo experiments, provide definitions of experimental biases and how to avoid them, and discuss major sources contributing to experimental biases and how to mitigate these sources.
General Principles of Preclinical Study Design - PubMed
网页In this chapter, we will focus on hypothesis testing type of preclinical studies and explain general concepts and principles in relation to the design of in vivo experiments, provide definitions of experimental biases and how to avoid them, and discuss major sources contributing to experimental biases and how to mitigate these sources.
Review Preclinical experimental models of drug metabolism …
网页2012年12月1日 · Understanding the pharmacokinetics of a compound in preclinical species with various dose routes (oral, intravenous, subcutaneous, transdermal, intraperitoneal, continuous infusion, intratracheal, as well as access ports of the portal vein) is an essential component for lead selection and optimization, and clinical candidate nomination and ...
Implementation of pharmacokinetic and pharmacodynamic …
网页2014年7月28日 · In this review, we emphasize the early implementation of hypothesis-driven preclinical experimental study designs, guided by model-based PK/PD analysis in the drug discovery phase. A well designed PK/PD strategy enables a project team to design the critical studies needed to address the team's key scientific hypotheses.
Bioassays in Experimental and Preclinical Pharmacology
网页This book explores protocols for preclinical pharmacology and toxicology evaluations to be applied to chemical drugs and their development through in vitro, involving tissues and cell lines, and in vivo models, using animals as experimental systems, utilized to conduct pharmacological research.
General Principles of Preclinical Study Design - ResearchGate
网页2019年11月10日 · In this chapter, we will focus on hypothesis testing type of preclinical studies and explain general concepts and principles in relation to the design of in vivo experiments, provide definitions...
Harnessing the predictive power of preclinical models for ... - Nature
网页2021年10月26日 · In this Review, we outline issues in preclinical-to-clinical translatability of molecularly targeted cancer therapies, present concepts and examples of successful reverse translation, and ...
Preclinical Pharmacokinetic/Pharmacodynamic Studies and Clinical …
网页2020年4月30日 · We investigated preclinical and clinical pre-approval studies to illuminate the current authorization process with emphasis on pharmacokinetic/pharmacodynamic approaches and clinical phases. All centrally authorized systemic antibacterial and antimycobacterial drugs within the European Union were …
Study of the principles in the first phase of experimental pharmacology ...
网页2019年5月21日 · Experimental pharmacology is the basic step in the discovery of new drug or studying the pharmacological actions of already developed one using both preclinical and clinical study designs in a stepwise phase of investigations .