RUNX3 - Wikipedia
网页RUNX3 plays a fundamental role in defense against early tumor formation. In response to growth factors, RUNX3 is acetylated by p300 to complex with bromodomain-containing protein 2 (BRD2; a member of the BET family of transcription co-regulators) [9] and to subsequent transient induction of CDKN1A and ARF. [10]
RUNX3 Gene - GeneCards | RUNX3 Protein | RUNX3 Antibody
网页2024年8月6日 · RUNX3 (RUNX Family Transcription Factor 3) is a Protein Coding gene. Diseases associated with RUNX3 include Leukemia and Myeloid Leukemia. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Gene expression (Transcription).
Runx3 drives a CD8 + T cell tissue residency program that is
网页2022年7月26日 · Ectopic expression of Runx3 in CD4+ T cells incited this TGF-β-transcriptional network to promote prolonged survival, decreased tissue egress, a microanatomical redistribution towards epithelial...
BIOI最新速递 | RUNX3：定位导向的基因组协调器 - 知乎
网页2023年6月12日 · RUNX3抑制Wnt信号通路中β-连环蛋白/TCF4复合物的形成，从而阻断Cdx2，Axin2，Cyclin D1和c-Myc的转录，并抑制增殖和侵袭。RUNX3还直接与Akt1启动子结合并抑制Akt1/β-连环蛋白/细胞周期蛋白D1信号轴，以另一种方式阻断Wnt信号通路。
RUNX3 in Stem Cell and Cancer Biology - PMC - National Center …
网页2023年1月25日 · The runt-related transcription factors (RUNX) play prominent roles in cell cycle progression, differentiation, apoptosis, immunity and epithelial–mesenchymal transition. There are three members in the mammalian RUNX family, each with distinct tissue expression profiles.
RUNX3 regulates cell cycle-dependent chromatin dynamics by
网页2019年4月23日 · We found that early after mitogenic stimulation, RUNX3 binds to its target loci, where it opens chromatin structure by sequential recruitment of Trithorax group proteins and cell-cycle regulators...
Runx3 programs CD8 + T cell residency in non-lymphoid tissues …
网页2017年12月6日 · The transcription factor Runx3 is identified as a central regulator of the development of tissue-resident memory CD8+ T cells, providing insights into the signals that promote T cell residency in...
Waiting in the wings: RUNX3 reveals hidden depths of immune ... - PubMed
网页Results: The available evidence on the immune roles of RUNX3 allowed for its description in twelve cell types: intraepithelial lymphocyte, Th1, Th2, Th17, Treg, double-positive T, cytotoxic T, B, dendritic, innate lymphoid, natural killer and macrophages. In the gut, the activity of RUNX3 is multifaceted and context-dependent: it may promote ...
Runx3 at the interface of immunity, inflammation and cancer
网页2015年4月1日 · RUNX3 is expressed in immune system cells but not in epithelium. • RUNX3 is not mutated, focally deleted or GWAS-linked with cancers. • RUNX3 and its targets are GWAS-linked with inflammatory diseases. • RUNX3 P2-promoter hypermethylation is not a driving event in cancer. • Runx3-deficiency affects epithelial tumors in a non-cell ...
Runx3 in Immunity, Inflammation and Cancer - PubMed
网页In this chapter we summarize the pros and cons of the notion that Runx3 is a major tumor suppressor gene (TSG). Inactivation of TSGs in normal cells provides a viability/growth advantage that contributes cell-autonomously to cancer. More than a decade ago it was suggested that RUNX3 is involved in g …