F.D.A. Approves GHB, a ‘Date Rape’ Drug, for Rare Sleeping Disorder
网页2021年8月12日 · Now, the Food and Drug Administration has approved the drug for a new use: treating “idiopathic hypersomnia,” a mysterious condition in which people sleep nine or more hours a day, yet never feel...
Neurophysiological signature of gamma-hydroxybutyrate augmented sleep ...
网页2019年4月8日 · Gamma-hydroxybutyrate (GHB) is an endogenous GHB/GABA B receptor agonist, which has demonstrated potency in consolidating sleep and reducing excessive daytime sleepiness in...
Neurophysiological signature of gamma-hydroxybutyrate augmented sleep ...
网页2019年4月8日 · Gamma-hydroxybutyrate (GHB) is an endogenous GHB/GABA B receptor agonist, which has demonstrated potency in consolidating sleep and reducing excessive daytime sleepiness in narcolepsy.
Gamma-hydroxybutyrate (GHB) for narcolepsy in adults: an …
网页GHB was found to improve cataplexy attacks (P = 0.001), subjective daytime sleepiness (P < 0.0001), daytime sleep latency (P < 0.0001), inadvertent naps/sleep attacks (P < 0.00001), effective rates (Clinical Global Impression of change) (P < 0.00001), hypnagogic hallucinations (P = 0.004), sleep paralysis (P = 0.004), stage 1 sleep (P = 0.04 ...
Gamma-hydroxybutyrate (GHB) for narcolepsy in adults: an …
网页2019年12月1日 · Narcolepsy is a chronic and debilitating sleep disorder characterized by cataplexy and excessive daytime sleeping. Gamma-hydroxybutyrate (GHB) has been widely used to treat narcolepsy, and new findings have been published in recent years.
网页GHB prolonged slow-wave sleep (stage N3) at the cost of rapid eye movement (REM) sleep. Furthermore, it enhanced delta–theta (0.5–8Hz) activity in NREM and REM sleep, while reducing activity in
Narcolepsy and effectiveness of gamma-hydroxybutyrate (GHB): a ... - PubMed
网页GHB increased sleep stages 3 + 4 (WMD 4.11; 95% CI 0.07/8.16, p = 0.05) and improved the CGI-c score (odds ratio (OR) 3.45; 95% CI 2.47/4.80, p < 0.00001). No significant changes were observed in night sleep latency, total sleep time, rapid-eye movement (REM) sleep and sleep stages 1 and 2.
网页GHB greatly increases the CNS depressant effects of alcohol and other depressants. What is its effect on the body? GHB takes effect in 15 to 30 minutes, and the effects last 3 to 6 hours. Low doses of GHB produce nausea. At high doses, GHB overdose can result in: • Unconsciousness, seizures, slowed heart rate, greatly
Current Insights on the Impact of Gamma-Hydroxybutyrate (GHB) …
网页2022年2月9日 · Recreational gamma-hydroxybutyrate (GHB) use, although less common than other substance use, is increasingly recognised and is over-represented in emergency toxicology presentations. This narrative review summarizes GHB pharmacology, current patterns of use, potential harms and management of GHB toxicity and withdrawal.
GHB: Best medication to treat severe sleep disorder
网页2005年6月28日 · Although dangerous when it is abused, GHB is the best – and currently only – FDA-approved medication to treat narcolepsy. “It normalizes sleep patterns, which is a quirky thing about GHB,” Dr. France says. Whereas sedative drugs interfere with the most restful phase of sleep, called REM or rapid eye movement, GHB increases it.