TIMP1（组织抑制金属蛋白酶1）是一种具有重要生物学功能的蛋白质
网页TIMP1最早是在上世纪80年代被发现并鉴定为一种能抑制基质金属蛋白酶（MMPs）的活性蛋白质。 MMPs是一类调节组织结构和功能的金属酶，它们能够分解和降解细胞外基质，参与许多生理和病理过程。 TIMP1通过与MMPs结合，形成不可溶的复合物，从而抑制MMPs的活性，阻止细胞外基质的降解。 除了抑制MMPs，TIMP1还具有多种其他功能。 研究表明，TIMP1可以通过与细胞表面受体结合，参与信号传导通路的调控。 特别是在肿瘤 …
TIMP1 - Wikipedia
网页TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). [6] In regulating MMPs, TIMP1 plays a crucial role in extracellular matrix (ECM) composition, wound healing, [7] and pregnancy. [8][9][10] The dysregulated activity of TIMP1 has been implicated in cancer. [11]
组织金属蛋白酶抑制剂 - 百度百科
网页组织金属蛋白酶抑制剂. 外文名. tissue inhibitor of matrix metalloproteinases,TIMPs. , 它可以 共价键 的形式与MMPs相结合成1：1复合体，特异性抑制MMPs的活性。. 正常情况下，MMPs和TIMPs相互作用，使 ECM 处于动态平衡中，MMPs活性增强或TIMPs活性降低都会破坏ECM的动态平衡 ...
TIMP-1 is an activator of MHC-I expression in myeloid ... - Nature
网页2024年5月22日 · This study uncovers the role of TIMP-1 in DC-mediated immunogenicity with insights into CD8 + T cell activation, providing a foundation for mechanistic exploration and highlighting its potential...
Recognizing the Molecular Multifunctionality and Interactome of TIMP-1
网页2018年9月19日 · TIMP-1 is a two-domain protein with multiple functions, and the list of its interaction partners has rapidly expanded in recent years. This review develops the first integrated view of multifunctionality as an important biological feature of TIMP-1.
TIMPs: versatile extracellular regulators in cancer - Nature
网页2016年12月9日 · Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell surface proteins, generating...
The Biology and Function of Tissue Inhibitor of Metalloproteinase …
网页2022年12月31日 · Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP). Altered MMP/TIMP ratios are frequently observed in several human diseases.
Cut loose TIMP-1: an emerging cytokine in inflammation - Cell Press
网页2022年9月23日 · Recently, TIMP-1 emerged as a potent cytokine acting via various cell-surface receptors, explaining a so-far under-appreciated role of TIMP-1-mediated signaling on immune cells. This, at least partly, resolved why elevated blood levels of TIMP-1 correlate with progression of numerous inflammatory diseases.
TIMP-1 is a novel ligand of Amyloid Precursor Protein and
网页2023年2月6日 · The emerging cytokine tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with the progression of inflammatory diseases, including cancer. However, the effects of TIMP-1 on immune cell activation and underlying molecular mechanisms are largely unknown.
Cytokine functions of TIMP-1 | Cellular and Molecular Life Sciences
网页2013年8月28日 · The present review summarizes the current knowledge on TIMP-1 as a cytokine modulator of cell functions, outlines recent progress in defining molecular pathways that transmit TIMP-1 signals from the cell periphery into the nucleus, and discusses TIMP-1’s role as a cytokine in the pathophysiology of cancer and other human diseases.
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