Tositumomab - Wikipedia
网页Tositumomab is a murine monoclonal antibody which targets the CD20 antigen produced in mammalian cell. [1] It was combined with iodine-131 to produce a radiopharmaceutical for unsealed source radiotherapy, Iodine-131 Tositumomab (branded as Bexxar), for the treatment of non-Hodgkins lymphoma. [1] It is classified as a IgG2a lambda antibody. [1] [2]
抗CD20单抗科普：从一代的利妥昔到三代的阿妥珠 - MedSci
网页2020年5月7日 · 利妥昔是全球第一个被批准用于治疗非霍奇金淋巴瘤的单克隆抗体，目前获FDA批准的适应症包括非霍奇金淋巴瘤（NHL）,慢性淋巴细胞白血病（CLL）, 类风湿性关节炎（RA）以及Wegener氏肉芽肿 (WG)和显微镜多血管炎 (MPA)。 利妥昔开创了淋巴瘤靶向治疗的先河，在利妥昔问世之前，传统化疗药物一直是治疗淋巴瘤的一线治疗方案。 目前，利妥昔和化疗药物CHOP（环磷酰胺、多柔比星、长春新碱、强的松）和CVP（环磷 …
Tositumomab: Uses, Interactions, Mechanism of Action
网页Tositumomab is a monoclonal anti-CD20 antibody used to treat B-cell non-Hodgkin's lymphoma via a conjugated radioactive isotope. Generic Name.
131I-Tositumomab Therapy as Initial Treatment for Follicular …
网页2005年2月3日 · The BEXXAR therapeutic regimen (tositumomab and iodine I 131 tositumomab) produced durable complete remissions in heavily pretreated patients with non-Hodgkin's lymphoma (NHL),...
Bexxar: Uses, Dosage, Side Effects, Warnings - Drugs.com
网页2024年7月17日 · Bexxar is injected into a vein through an IV. You will receive two different injections (tositumomab, and iodine I-131 tositumomab) given one at a time. The first injection is given over at least 60 minutes and the second injection is given over at least 20 minutes. Bexxar treatment is usually given in two steps over a span of 7 days.
Efficacy and safety of new anti-CD20 monoclonal antibodies …
网页2021年2月5日 · Rituximab combined with chemotherapy is the first-line induction therapy of CD20 positive B-cell non-Hodgkin lymphomas (CD20 + B-NHL). Recently new anti-CD20 monoclonal antibodies (mAbs) have been...
Tositumomab and 131I Therapy in Non-Hodgkin’s Lymphoma
网页2005年1月1日 · Tositumomab and 131 I-tositumomab constitute a relatively new radioimmunotherapeutic regimen for patients with CD20+ follicular non-Hodgkin’s lymphoma (NHL).
Bexxar® - Frequently Asked Questions About Bexxar® (tositumomab)
网页2018年6月1日 · In the dosimetric step, patients will be administered Bexxar, followed by a small dose of the radioactive material, I131 tositumomab. The radioactive material emits radiation detectable by a special scanner or camera, called a gamma camera.
Safety and Efficacy of I(131) Tositumomab in the Treatment of …
网页2009年7月1日 · 131 I Tositumomab has demonstrated remarkable clinical activity in patients with relapsed follicular lymphoma with high response rates and durable remission even in patients with disease that is refractory to chemotherapy and rituximab antibody therapy. Recent new data has provided new insights into the potential mechanisms of the antibody and ...
131I–Tositumomab in lymphoma - PMC - National Center for ...
网页131 I–Tositumomab (Bexxar: Corixa Corporation, South San Francisco, CA, and GlaxoSmithKline, Philadelphia, PA, U.S.A.) is a radioimmunoconjugate consisting of an anti-CD20 murine monoclonal antibody (tositumomab) covalently bound to the gamma-emitting radioactive isotope 131 I 5, 6.
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