Co-Regulated Genes and Gene Clusters - PubMed
网页2021年6月11日 · There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, wh ….
Co-Regulated Genes and Gene Clusters - PMC - National Center …
网页2021年6月11日 · As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with similar functions. In this aspect, they differ significantly from bacterial operons containing functionally linked genes that are not paralogs.
Co-regulation - Wikipedia
网页Co-regulation (or coregulation) is a term used in psychology. It is defined most broadly as a "continuous unfolding of individual action that is susceptible to being continuously modified by the continuously changing actions of the partner".
Identification of co-regulated genes through Bayesian clustering …
网页2003年3月10日 · The identification of co-regulated genes and their transcription-factor binding sites (TFBS) are key steps toward understanding transcription regulation. In addition to effective laboratory...
Assigning Co-Regulated Human Genes and Regulatory Gene …
网页2021年9月12日 · We show that 14,636 of 33,488 genetically regulated genes (43.7%) are co-regulated together with at least one other gene, resulting in 14,727 unique expression clusters across the tissues analyzed.
Colocalization of Coregulated Genes: A Steered Molecular ... - PLOS
网页2013年3月28日 · The colocalization of the coregulated gene pairs was finally imposed by applying a steered molecular dynamics protocol. It was found that most of the coregulated pairs could be colocalized in space when the steering protocol was applied to chromosomes initially prepared in mitotic-like and interphase-like arrangements, see Fig. 2.
Quantifying the relationship between co-expression, co-regulation …
网页2004年2月25日 · We demonstrate how mRNA expression data and functional annotations can be used together to estimate the probability that genes share a common regulatory mechanism. Existing microarray data and known functional annotations are sufficient to identify only a relatively small percentage of co-regulated genes.
Colocalization of coregulated genes: a steered molecular
网页The connection between chromatin nuclear organization and gene activity is vividly illustrated by the observation that transcriptional coregulation of certain genes appears to be directly influenced by their spatial proximity.
Chromosomal Contact Permits Transcription between Coregulated Genes
网页Transcription of coregulated genes occurs in the context of long-range chromosomal contacts that form multigene complexes. Disruption of the contacts shows that they are necessary for transcription and that not all genes have equal impact on the transcription of the others but, rather, exhibit a hierarchy of influence.
Assigning Co-Regulated Human Genes and Regulatory Gene …
网页2021年9月12日 · Elucidating the role of genetic variation in the regulation of gene expression is key to understanding the pathobiology of complex diseases which, in consequence, is crucial in devising targeted treatment options. Expression quantitative trait locus (eQTL) analysis correlates a genetic variant with ….
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