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Setd2 supports GATA3+ST2+ thymic-derived Treg cells and
网页2022年12月3日 · Transcription characteristics of Treg cells are regulated by epigenetic modifications, the mechanism of which remains obscure. Here, we report that Setd2, a histone H3K36 methyltransferase, is ...
Setd2 supports GATA3+ST2+ thymic-derived Treg cells and
网页2022年12月3日 · Here, we report that Setd2, a histone H3K36 methyltransferase, is important for the survival and suppressive function of Treg cells, especially those from the intestine. Setd2 supports GATA3 + ST2 + intestinal thymic-derived Treg (tTreg) cells by facilitating the expression and reciprocal relationship of GATA3 and ST2 in tTreg cells.
Characters: Qiang Jin Jiu – cangji.net
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