Human Interleukin-6 (hIL-6) #8904 - Cell Signaling Technology …
网页IL-6 is a potent inducer of the acute phase response and is produced by T cells, macrophages, fibroblasts, endothelial and other cells (1,2). IL-6 induces proliferation and differentiation and acts on B cells, T cells, thymocytes, and others. IL-6 in concert with TGFβ is important for developing Th17 responses.
Unveiling novel insights into human IL-6 − IL-6R interaction sites ...
网页2024年8月7日 · The cytokine interleukin-6 (IL-6) plays a crucial role in autoimmune and inflammatory diseases. Understanding the precise mechanism of IL-6 interaction at the amino acid level...
IL-6 trans-signaling promotes the expansion and anti-tumor
网页2020年11月9日 · First, we showed that in the presence of hyper IL-6 (HIL-6), a synthetic IL-6/sIL-6R complex that stimulates IL-6 trans-signaling, CAR T cells exhibit improved expansion, reduced apoptosis,...
Transneuronal delivery of hyper-interleukin-6 enables ... - Nature
网页2021年1月15日 · This is achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hyper-IL-6 (hIL-6), a potent designer cytokine stimulating JAK/STAT3 signaling and axon...
Molecular dynamics analysis of the binding of human interleukin-6 …
网页Human interleukin-6 (hIL-6) is a multifunctional cytokine that regulates immune and inflammatory responses in addition to metabolic and regenerative processes and cancer. hIL-6 binding to the IL-6 receptor (IL-6Rα) induces homodimerization and recruitment of the glycoprotein (gp130) to form a hexameric signaling complex.
Viral Interleukin-6: Structure, pathophysiology and strategies of ...
网页Viral Interleukin-6 (vIL-6) is encoded by Human herpes virus 8 (HHV8), also known as Kaposi's sarcoma (KS)-associated herpes virus (KSHV). HHV8 infection is found in patients with KS, primary effusion lymphoma (PEL) and plasma cell-type of multicentric Castleman's disease (MCD), with a high incidenc ….
Exclusive inhibition of IL-6 trans-signaling by soluble gp130
网页2021年11月29日 · HIL-6 is a fusion protein of IL-6 and the soluble IL-6R connected by a flexible peptide linker. HIL-6 mimics trans-signaling and is a potent inducer of cells expressing gp130. Introduction of R281Q in sgp130 R281Q Fc and sgp130 FlyR Fc only minimally affects the binding affinity to HIL-6 compared to …
Expression, purification and characterization of soluble human ...
网页2007年5月30日 · Human interleukin-6 (hIL-6) is a multifunctional cytokine, which plays a central role in immune responses and inflammatory reactions.
Molecular dynamics analysis of the binding of human interleukin‐6 …
网页2020年9月2日 · Human interleukin‐6 (hIL‐6) is a multifunctional cytokine that regulates immune and inflammatory responses in addition to metabolic and regenerative processes and cancer. hIL‐6 binding to the IL‐6 receptor (IL‐6Rα) induces homodimerization and recruitment of the glycoprotein (gp130) to form a hexameric signaling complex.
Transneuronal delivery of hyper-interleukin-6 enables functional ...
网页2021年1月15日 · This is achieved by the unilateral transduction of cortical motoneurons with an AAV expressing hyper-IL-6 (hIL-6), a potent designer cytokine stimulating JAK/STAT3 signaling and axon regeneration. We find collaterals of these AAV-transduced motoneurons projecting to serotonergic neurons in both sides of the raphe nuclei.
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