Lentivirus - Wikipedia
网页Visna-maedi virus. (+5 endogenous found) [1] Lentivirus is a genus of retroviruses that cause chronic and deadly diseases characterized by long incubation periods, in humans and other mammalian species. [2] The genus includes the human immunodeficiency virus (HIV), which causes AIDS.
慢病毒 - 百度百科
网页慢病毒载体（Lentiviral vector）较 逆转录病毒载体 有更广的 宿主范围，慢病毒能够有效感染 非周期性 和 有丝分裂 后的细胞。. 慢病毒载体能够产生表达shRNA的高 滴度 的慢病毒，在周期性和非周期性细胞、干细胞、 受精卵 以及分化的后代细胞中表达shRNA，实现在 ...
Lentiviral Guide - Addgene
网页Lentiviruses are a subtype of retrovirus. From an experimental standpoint the main difference between lentiviruses and standard retroviruses (γ-retroviruses) is that lentiviruses are capable of infecting non-dividing and actively dividing cell types whereas standard retroviruses can only infect mitotically active cell types.
Lentivirus - an overview | ScienceDirect Topics
网页Lentiviruses are a genus of retroviruses (family Retroviridae) that infect several mammalian species, including humans. Although most commonly known for the human immunodeficiency virus (HIV), this genus includes several other lentiviruses that trigger serious persistent and chronic infections in their hosts [1,2] .
Large-Scale Production of Lentiviral Vectors: Current Perspectives …
网页2020年11月3日 · The transformation of lentiviruses into viral vectors consists of separating the sequences needed for packaging and production from those encoding unnecessary viral proteins. First-generation HIV-based LVs separated the necessary elements of …
Clinical use of lentiviral vectors | Leukemia - Nature
网页2018年3月22日 · Two unique steps of the retroviral life cycle, reverse transcription and integration, are integral to how lentiviral vectors function. Following uncoating, the remaining viral nucleic acid and ...
Lentivirus - an overview | ScienceDirect Topics
网页Lentiviruses are a subclass of retroviruses containing RNA genomes that are capable of transducing genes into both dividing and nondividing cells. 37 Unlike adenoviruses, lentiviruses stably integrate into the host genome and are transmitted to cell progeny, making them more attractive for studies in most dividing cells and for experiments ...
Lentiviral vectors in gene therapy: their current status and …
网页A large number of viruses with unique characteristics useful for gene therapy have been identified. This has led to the application of recombinant viruses such as adenoviruses, adeno-associated viruses, herpes viruses, poxviruses, retroviruses and more recently lentiviruses, both in the laboratory and clinic.
The Inside Out of Lentiviral Vectors - PMC - National Center for ...
网页2011年2月14日 · Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy.
The Revival of Lentiviral Vectors - Nature
网页The idea was to co-opt a virus’ natural ability to target cells, transverse the membrane and deliver genetic cargo for novel gene-based therapies. But like many early-stage technologies ...