Osteocalcin - Wikipedia
网页Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid [5]) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. [6] Because osteocalcin has gla domains, its synthesis is vitamin K dependent.
Osteocalcin Test: Low & High Levels & How to Improve
网页2021年1月19日 · Osteocalcin is a protein that helps build and maintain bones. Read on to learn more about the osteocalcin test, normal levels, what low and high osteocalcin levels mean, and what you can do to improve your bone health.
What Is Osteocalcin? Definition, Function & Health Effects
网页2021年1月19日 · Osteocalcin is an important protein that is important for strong bones. It also acts as a hormone to adjust insulin and glucose levels, increase testosterone, and improve muscle strength and cognitive function. Read on to learn more about osteocalcin and its complex role in health.
New Insights into the Biology of Osteocalcin - PMC
网页Osteocalcin has routinely been used as a serum marker of osteoblastic bone formation and believed to act in the bone matrix to regulate mineralization, but new genetic and pharmacologic evidence now points to a hormonal role for the protein.
New insights into the biology of osteocalcin - PubMed
网页Osteocalcin is among the most abundant proteins in bone and is produced exclusively by osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies suggest a broader role for osteocalcin that extends to the regulation of whole body metabolism, reproduction, and cognition ….
Osteocalcin: A Multifaceted Bone-Derived Hormone - PubMed
网页2023年8月21日 · Together, loss- and gain-of-function experiments have identified the bone-derived secreted molecule osteocalcin as a hormone with a broad reach in rodents and primates.
Osteocalcin—A Versatile Bone-Derived Hormone - Frontiers
网页2019年1月9日 · One of the key players in bone endocrinology is osteocalcin, or bone γ-carboxyglutamic acid protein, a factor expressed and secreted solely by osteoblasts (1).
Update on the Biology of Osteocalcin - Endocrine Practice
网页At the onset of exercise, bone secretes osteocalcin, which increases nutrient uptake and catabolism in myofibers to produce ATP. On the other hand, osteocalcin signaling in myofibers enhances IL-6 production during exercise, IL-6 then signals bone cells to promote bioactive osteocalcin production.
Osteocalcin and the physiology of danger - PMC - National …
网页This review will focus on this emerging aspect of bone biology taking osteocalcin as a case study and will show how classical and endocrine functions of bone help to define a new functional identity for this tissue. Keywords: inter-organ communication, osteocalcin, response to danger, skeleton.
Osteocalcin: A Multifaceted Bone-Derived Hormone - PMC
网页2023年8月8日 · Together, loss- and gain-of-function experiments have identified the bone-derived secreted molecule osteocalcin as a hormone with a broad reach in rodents and primates.
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