Piperaquine - Wikipedia
网页Piperaquine is an antiparasitic drug used in combination with dihydroartemisinin to treat malaria. Piperaquine was developed under the Chinese National Malaria Elimination Programme in the 1960s and was adopted throughout China as a replacement for the structurally similar antimalarial drug chloroquine.
Piperaquine: Uses, Interactions, Mechanism of Action - DrugBank …
网页Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China 1. Its use declined in the 1980's as piperaquine resistant strains of Plasmodium falciparum appeared and artemisinin derivatives became available.
Dihydroartemisinin–Piperaquine for the Prevention of Malaria in ...
网页2016年3月10日 · Dihydroartemisinin–piperaquine has been shown to be effective for the treatment of malaria in pregnant and nonpregnant populations 29,30 and for the prevention of malaria in children and ...
Piperaquine: a resurgent antimalarial drug - PubMed
网页Piperaquine is a bisquinoline antimalarial drug that was first synthesised in the 1960s, and used extensively in China and Indochina as prophylaxis and treatment during the next 20 years. A number of Chinese research groups documented that it was at least as effective as, and better tolerated than, ….
Piperaquine - an overview | ScienceDirect Topics
网页Piperaquine is structurally similar to chloroquine with the same mechanism of action against Plasmodium. Piperaquine was used as the first-line treatment for malaria in China for many years before the emergence of resistance in the 1990s. It is now used in combination with artenimol but only in areas with sensitivity.
Dihydroartemisinin‐piperaquine for treating uncomplicated …
网页2014年1月20日 · Dihydroartemisinin‐piperaquine for treating uncomplicated malaria. This review summarises trials evaluating the effects of dihydroartemisinin‐piperaquine (DHA‐P) compared to other artemisinin‐based combination therapies recommended by the World Health Organization.
Frontiers | Efficacy and Safety of Artemisinin-Piperaquine for the ...
网页2020年9月10日 · Piperaquine is a 4-chloroquinoline compound (1,3-bis [1- (7-chloro-4’-quinolyl)-4’-piperazinyl]) that was used in China in 1970s–80s. Reportedly, as compared with piperaquine phosphate, patients showed better tolerance to piperaquine; moreover, piperaquine could help reduce the treatment expense and time (Davis et al., 2005; Krudsood et al., 2007).
Piperaquine Pharmacokinetics during Intermittent Preventive …
网页2021年2月17日 · Dihydroartemisinin-piperaquine (DP) is a long-acting artemisinin combination treatment that provides effective chemoprevention and has been proposed as an alternative antimalarial drug for intermittent preventive therapy in pregnancy (IPTp).
Piperaquine - an overview | ScienceDirect Topics
网页Piperaquine is a bisquinoline antimalarial developed in the 1960s by Shangai Pharmaceutical Industry Research (China) and Rhone Poulec (France) and widely used in China for over 20 years (Figure 3 [23]).
Piperaquine | C29H32Cl2N6 | CID 122262 - PubChem
网页Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China. Its use declined in the 1980's as piperaquine resistant strains of *Plasmodium falciparum* appeared and artemisinin derivatives became available.