Polysialic acid - Wikipedia
网页Polysialic acid (polySia) is polymer of linearly repeating monomer units of α2,8- and α2,9-glycosidic linked sialic acid residues. Sialic acid refers to carboxylated 9-carbon sugars, 2-keto-3-dexoxy-D-glycero-nononic acids. [1] An unusual property of this sugar is that it often polymerizes into polySia.
The polyfunctional polysialic acid: A structural view
网页2021年9月1日 · Polysialic acid (polySia), a homopolymer of α2,8-linked sialic acid residues, modifies a small number of proteins and has central functions in vertebrate signalling. Here, we review the regulatory functions of polySia in signalling processes and the immune system of adult humans, as well as …
Sialic acid and biology of life: An introduction - PMC
网页2020年1月17日 · Sialic acids or N -acetylneuraminic acids (Neu5Ac) are a diverse group of 9‑carbon carboxylated monosaccharides synthesized in animals, present at the outermost end of N -linked and O -linked carbohydrate chains and in lipid-associated glycoconjugates (Fig. 1 , 1–6) and lack in plants [6].
The different prognostic significance of polysialic acid and CD56 ...
网页2022年7月2日 · Through immunohistological analysis of breast cancer patient tumors, we have discovered the expression of an atypical glycan—polysialic acid (polySia)—in breast cancer.
Polysialic Acid in the Immune System - PMC - National Center for ...
网页2022年2月11日 · Polysialic acid (polySia) is a highly regulated polymer of sialic acid (Sia) with such potent biophysical characteristics that when expressed drastically influences the interaction properties of cells.
Polysialic acid in the plasticity of the developing and adult ...
网页Polysialic acid (PSA) is a cell-surface glycan that has an enormous hydrated volume that serves to modulate the distance between cells and, thereby, the strength of their interaction. PSA...
Polysialic Acid - SpringerLink
网页2014年1月1日 · Polysialic acid (polySia), particularly α2,8-linked polyNeu5Ac (DP = 8 ~ 400), is a unique polymer of sialic acid (Sia) and modifies neural cell adhesion molecule (NCAM) spatiotemporally in embryonic brains. PolySia is involved in cell migration, neural...
The polyfunctional polysialic acid: A structural view - PubMed
网页Polysialic acid (polySia), a homopolymer of α2,8-linked sialic acid residues, modifies a small number of proteins and has central functions in vertebrate signalling. Here, we review the regulatory functions of polySia in signalling processes and the immune system of adult humans, as well as function ….
Bioproduction, purification, and application of polysialic acid
网页2018年9月22日 · Polysialic acid (PSA) is a negatively charged linear homopolymer linked by N-acetylneuraminic acid and widely present in vertebrates and some pathogens. PSA, commonly found on cell surfaces as glycoproteins and glycolipids, plays important roles in intercellular adhesion, cell migration, and formation and remodeling of …
Polysialic acid sustains cancer cell survival and migratory
网页2016年9月9日 · Polysialic acid (polySia) is a unique carbohydrate polymer expressed on the surface of NCAM (neuronal cell adhesion molecule) in a number of cancers where it modulates cell-cell and cell-matrix...
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