Serotonin transporter - Wikipedia
网页SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic neuron, in a process known as serotonin reuptake. [6] This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner.
X-ray structures and mechanism of the human serotonin transporter
网页2016年4月6日 · SERT is a target for antidepressant and psychostimulant drugs, which block reuptake and prolong neurotransmitter signalling. Here we report X-ray crystallographic structures of human SERT at...
Illumination of serotonin transporter mechanism and role of …
网页2021年12月1日 · The serotonin transporter (SERT) terminates serotonin signaling by using sodium and chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of widely used medications to treat neuropsychiatric disorders. Despite decades of study, the molecular mechanism of serotonin transport, the coupling to ion gradients ...
Sci Adv | 科学家揭示五羟色胺转运蛋白运输和别构调节机制 - 知乎
网页五羟色胺转运蛋白 （serotonin transporter: SERT）是 神经递质钠同向转运蛋白 (neurotransmitter sodium sympoter: NSS) 家族的成员，是治疗重度抑郁症和焦虑症的药物靶点。. 除了传统的中心位点（S1）外，研究人员发现在SERT的细胞外暴露区域还有第二个小分子结合位点，称为 ...
Conformational dynamics of the human serotonin transporter …
网页2019年4月11日 · The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin...
Ligand coupling mechanism of the human serotonin transporter ...
网页2024年1月10日 · The presynaptic serotonin transporter (SERT) clears extracellular serotonin following vesicular release to ensure temporal and spatial regulation of serotonergic...
Illumination of serotonin transporter mechanism and role of the ...
网页2021年12月1日 · The serotonin transporter (SERT) terminates serotonin signaling by using sodium and chloride gradients to drive reuptake of serotonin into presynaptic neurons and is the target of widely used medications to treat neuropsychiatric disorders. Despite decades of study, the molecular mechanism of serotonin transport, the coupling to ion gradients ...
Multifaceted Regulations of the Serotonin Transporter: Impact on ...
网页2019年2月12日 · Serotonin transporter, SERT ( SLC64A for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na + gradient established by the electrogenic pump Na/K ATPase.
SERT ® Suite - Standard Performance Evaluation Corporation
网页This next-generation measurement standard was designed in collaboration with leaders of global energy-efficiency regulatory programs. The SERT 2.0.4 Suite supports certification of the latest ARM, Power, and x86 architectures driving global regulatory energy goals.
Serotonin Transporter - an overview | ScienceDirect Topics
网页The serotonin transporter is a protein critical to regulating serotonin function in the brain. Serotonin plays a pivotal role in many forms of psychopathology, with the specific serotonin reuptake inhibitors and other serotonin agents being some of the most widely prescribed psychotropic medications.