Most common ‘sporadic’ cancers have a significant germline …
网页2014年11月11日 · In eight of the twelve cancers studied, there was a significant polygenic component, that is, a large number of genes of weak effect are involved. Given a polygenic basis to disease, it has been shown that most people who develop cancer would be ‘sporadic cases’ (no affected first-, second- or third-degree relatives) . …
Cancer Genetics Overview (PDQ®) - NCI - National Cancer Institute
网页2024年8月23日 · Cancer Genetics Overview discusses hereditary cancers and the role of genetic variants (mutations). Get information about genetic counseling, familial cancer syndromes, genomic sequencing, germline and somatic testing, ethical and legal issues and more in this summary for clinicians.
Sporadic Cancers - SpringerLink
网页2016年11月13日 · The majority of cancers develop sporadically. In contrast to hereditary cancers with a single genetic factor of high penetrance, the reason why sporadic cancer develops seems to be multifold. In a minority of sporadic cancers, a single …
Definition of sporadic cancer - NCI Dictionary of Cancer Terms
网页Cancer that occurs in people who do not have a family history of that cancer or an inherited change in their DNA that would increase their risk for that cancer.
Definition of sporadic cancer - NCI Dictionary of Genetics Terms
网页sporadic cancer. Cancer that occurs in people who do not have an inherited genetic variant that would increase their risk for that cancer. Sporadic cancer is sometimes used to differentiate cancers that occur in these people from cancers that occur in people who are known or likely to carry a high-risk variant that increases their risk for cancer.
Genomic instability — an evolving hallmark of cancer
网页In sporadic (non-hereditary) cancers the molecular basis of genomic instability remains unclear, but recent high-throughput sequencing studies suggest that mutations in DNA repair genes are...
Hallmarks of 'BRCAness' in sporadic cancers - Nature Reviews Cancer
网页Emerging evidence indicates that these processes are disrupted by numerous mechanisms in sporadic cancers. Collectively, there are properties that define 'BRCAness' — that is, traits that some...
Genetic pathways, prevention, and treatment of sporadic colorectal cancer
网页2014年6月30日 · Genetic pathways of sporadic colon cancer. It is well established that sporadic CRC is a genetic disease caused by sequential accumulation of mutations in multiple genes. Over the past three decades, molecular genetic studies have identified several crucial gene defects that underlie predisposition to sporadic CRC .
MYC upstream region orchestrates resistance to PI3K inhibitors in ...
网页1 天前 · Through comprehensive investigations in MYC-driven Colorectal Cancer (CRC) and Burkitt Lymphoma (BL) cells, we demonstrate that MYC UR does not facilitate cap-independent translation, but instead ...
Molecular pathogenesis of sporadic colorectal cancers - PMC
网页2016年1月6日 · Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic and occur in people without genetic predisposition or family history of CRC.