网页FAS is a transmembrane receptor expressed on all acti-vated lymphocytes. It induces apoptotic cell death but can also mediate nonapoptotic functions (Klebanoff et al., 2016; Le Gallo et al., 2017; Peter et al., 2007). Lymphoproliferation in ALPS is mainly caused by accumula-tion of polyclonal CD3+TCRαβ+CD4−CD8− double-negative T cells (DNTs).
网页Introduction. The chemokine receptor CCR5 and its ligands CCL3 (MIP1α), CCL4 (MIP1 and CCL5 β) (RANTES) play an important role in orchestrating the inflammatory response [1]. CCR5 medi-ated inflammation may play an important role in promoting the growth of tumours[2] and in other diseases exhibiting chronic inflammatory pathologies [3].
网页Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlandsa; Infectious Diseases Discovery & Translational Area, Roche Innovation Center Basel, Basel, Switzerlandb. ABSTRACT.