Trifluoromethyl group - Wikipedia
网页The trifluoromethyl group is a functional group that has the formula -CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF. 3, 1,1,1-trifluoroethane H. 3C – CF.
Trifluoromethyl Group - an overview | ScienceDirect Topics
网页A trifluoromethyl group is defined as a substituent in organic chemistry with unique stereoelectronic properties, characterized by high electronegativity and close Van-der-Waals radii. It plays a crucial role in drug-receptor interactions by increasing lipophilicity and improving transport characteristics of bioactive molecules.
三氟甲基 - 维基百科，自由的百科全书
网页三氟甲基 （英语：trifluoromethyl）是一個 有機氟化合物 的官能团，化学式为-CF 3。 為 氟原子 取代甲基（-CH 3）上的所有氫原子而成。 三氟甲基聚集高 電负性，一般認為介于在氟 (4.0)和氯 (3.0)之間。 因此，带有三氟甲基的化合物通常是强酸，比如 三氟甲磺酸 和 三氟乙酸。 在化學合成時，可能可以在有機化合物加入三氟甲基官能基以降低鹼度，或賦予獨特的溶劑性質（例如 三氟乙醇）。 三氟甲基官能基存在于某些藥品、毒品和非生物合成氟碳 …
Trifluoromethylation - Wikipedia
网页Trifluoromethylation in organic chemistry describes any organic reaction that introduces a trifluoromethyl group in an organic compound. [1][2][3][4] Trifluoromethylated compounds are of some importance in pharmaceutical industry and agrochemicals.
A scalable and operationally simple radical trifluoromethylation …
网页2015年8月10日 · Here we report a strategy for the use of trifluoroacetic anhydride for a scalable and operationally simple trifluoromethylation reaction using pyridine N -oxide and photoredox catalysis to affect...
Radical trifluoromethylation - Chemical Society Reviews (RSC …
网页2021年4月23日 · The trifluoromethyl group plays an increasingly important role in pharmaceuticals, agrochemicals and materials. This tutorial describes recent advances in trifluoromethylation of carbon-centered radical intermediates.
Benzene, (trifluoromethyl)- - NIST Chemistry WebBook
网页Formula: C 7 H 5 F 3. Molecular weight: 146.1098. IUPAC Standard InChI:InChI=1S/C7H5F3/c8-7 (9,10)6-4-2-1-3-5-6/h1-5H Copy. IUPAC Standard InChIKey:GETTZEONDQJALK-UHFFFAOYSA-N Copy. CAS Registry Number: 98-08-8.
Recent advances in the trifluoromethylation methodology and new …
网页2014年11月1日 · The development of a catalytic method in copper constituted a landmark in the trifluoromethylation of arenes. This involved the reaction of electron-deficient aryl iodides with CF 3 SiEt 3 and a catalytic amount of CuI in the presence of a chelating diamine ligand, 1,10-phenanthroline (phen) [10].
Regioselective trifluoromethylation of - Nature
网页2014年3月13日 · Herein we present a general and reliable method for the synthesis of trifluoromethyl group-containing N-heteroaromatics through highly regioselective addition of a trifluoromethyl nucleophile...
Direct nucleophilic trifluoromethylation of carbonyl compounds by ...
网页2018年7月31日 · In summary, we have developed an advantageous, simple and high-yielding method to trifluoromethylation of ketones, chalcones and aldehydes to the corresponding trifluoromethyl carbinols with HCF...