2,3-Dimercapto-1-propanesulfonic acid - Wikipedia
网页2,3-Dimercapto-1-propanesulfonic acid (abbreviated DMPS) and its sodium salt (known as Unithiol) are chelating agents that form complexes with various heavy metals. They are related to dimercaprol, which is another chelating agent. The synthesis of DMPS was first reported in 1956 by V. E. Petrunkin. [2] The effects of DMPS on heavy metal ...
Unithiol - an overview | ScienceDirect Topics
网页Unithiol is a chelator structurally related to dimercaprol. It is water-soluble and reported to be less toxic than dimercaprol. Unithiol is used in the treatment of poisoning by heavy metals including arsenic, lead, and inorganic and organic mercury compounds.
2,3-二巯基丙磺酸 - 维基百科，自由的百科全书
网页2,3-二巯基丙磺酸 （英文缩写：DMPS），它的钠盐（商品名：Unithiol、Dimaval、螯金拔）作为 螯合剂 可以与多种重金属离子螯合，因此可以作为重金属中毒的 解毒剂。. 合成2，3-二巯基丙磺酸的方法是由来自基辅的Petrunkin在1956年首先报道的 [1]，随后以Unithiol的药 …
Unithiol (DMPS) - SpringerLink
网页2016年1月1日 · Unithiol (C 3 H 7 NaO 3 S 3; molecular weight 210 g/mol) (Fig. 1) is a crystalline solid that is freely soluble in water. It normally crystallizes as a monohydrate. The thiol groups are relatively stable but become increasingly subject to oxidation under alkaline conditions (pH >7).
Unithiol | C3H7NaO3S3 | CID 2724039 - PubChem
网页Unithiol | C3H7NaO3S3 | CID 2724039 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
CHAPTER 3-79: UNITHIOL (DMPS) - McGraw Hill Medical
网页Unithiol (DMPS; 2,3-dimercaptopropanol-sulfonic acid), a dimercapto chelating agent that is a water-soluble analog of BAL, is used in the treatment of poisoning by several heavy metals, principally mercury, arsenic, and lead. Available on the official formularies of Russia and former Soviet countries since 1958 and in Germany since 1976 ...
TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming …
网页2022年3月14日 · Unithiol shows promise as a venom inhibitor based on robust pre-clinical measures of efficacy. The advantages of unithiol over antivenom are that it is safe, orally available, demonstrates cross-species specificity and is cheaper to produce.
Drug Repurposing of the Unithiol: Inhibition of Metallo-&beta ...
网页2022年2月6日 · We describe here the inhibitory potency of known detoxifying antidote 2,3-dimercaptopropane-1-sulfonate (unithiol) against metallo-β-lactamases. Unithiol acts as a competitive inhibitor of meropenem hydrolysis by recombinant metallo-β-lactamase NDM-1 with the K I of 16.7 µM.
Drug Repurposing of the Unithiol: Inhibition of Metallo-β …
网页2022年2月6日 · Unithiol acts as a competitive inhibitor of meropenem hydrolysis by recombinant metallo-β-lactamase NDM-1 with the K I of 16.7 µM. It is an order of magnitude lower than the K I for l -captopril, the inhibitor of angiotensin-converting enzyme approved as a drug for the treatment of hypertension.
unithiol | C3H7NaO3S3 - ChemSpider
网页ChemSpider record containing structure, synonyms, properties, vendors and database links for unithiol, 4076-02-2, antidote.
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