Louisville is a very interesting team to follow. They are well coached by an underrated Jeff Brohm and always seem to maximize output relative to the overall talent in the building. They also seem to have a penchant for playing Notre Dame tough. Notre Dame must be properly prepared and motivated for this moment. I know Louisville will be.

Notre Dame is nearly a touchdown favorite against Louisville at most sportsbooks, as they look to exact some revenge after a loss to the Cardinals last season.

Our Louisville vs. Notre Dame predictions expect the Irish to get a win in what should be a low-scoring affair.