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科学家发现特殊吲哚萜天然产物抑制自噬机制
本报讯(见习记者江庆龄)华东理工大学药学院副教授何薇薇课题组与中国科学院上海有机化学研究所研究员李昂课题组合作,发现吲哚萜天然产物hapalindole Q是一个机制独特的自噬后期抑制剂,能够通过降解YAP1干扰自噬体与溶酶体融合,有望推动自噬相关疾病及Hippo-YAP相关疾病的先导化合物发现。近期,相关研究成果发表于美国《国家科学院院刊》。
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