Amyloid plaques comprising tangled fibrils of misfolded proteins are well-known drivers of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, but they are also present ...

Inert amyloid fibrils of the Alzheimer's Aβ-peptide 1–42 (Aβ 42) were incubated overnight with liposomes and various lipids including cholesterol, sphingolipids, gangliosides and brain extract.

Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing ...

Sometimes these TTR proteins can break apart, misfold, and accumulate in your heart as amyloid fibrils. This can cause the ...

It is caused by the buildup of toxic proteins called amyloid fibrils throughout the body. The amyloid fibrils damage tissues ...

Preclinical studies have shown AT-02 is able to bind to multiple amyloid types and can induce macrophage mediated amyloid phagocytosis and removal. The Food and Drug Administration has granted Orphan ...

Amyloid beta, TDP-43, and SOD-1 PFFs. These products support and accelerate the development of reliable neurodegenerative disease models. Tau TAU-H5115 Human Tau-441/2N4R Pre-formed Fibrils ...

Anselamimab is a monoclonal antibody commercialized by AstraZeneca, with a leading Phase III program in Primary Systemic Amyloidosis.

His lab is also exploring the efficacy of the curry spice extract, curcumin, to control inflammation and oxidative damage and to act directly on insoluble amyloid fibrils in plaques and more soluble ...