These lipid-laden macrophages cause immunosuppression ... Inhibiting the protein CD36 with sulfosuccinimidyl oleate (SSO) prevented the uptake of myelin debris, whereas blockade of the lipid ...

【导读】作为癌症中最常见的基因改变，超过一半的人类癌症具有导致转录失活的p53突变。然而，p53如何调节免疫景观以创造免疫逃逸的生态位，仍然难以捉摸。团队发现癌症干细胞（CSCs）建立了白细胞介素34（IL-34）编排的生态位，以促进p53灭活肝癌的 ...

A high density of tumor-associated macrophages (TAMs) is associated with poorer prognosis and survival in breast cancer patients. Recent studies have shown that lipid accumulation in TAMs can promote ...

Oxidative modification of photoreceptor disk proteins or membrane lipids may also be involved in recognition of damaged disks by RPE cell CD36 receptors that mediate endocytosis of ROS tips (15). In ...

研究成果于 2024 年 9 月 24 日以“ Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation ” 为题，在线发表于 Immunity 杂志 ...

These cells deal with microbes and repair tissue damage. Two main sub-types of immune cells are T cells and macrophages. T cells are designed to recognise the molecular signatures of particular ...

The proposed mechanisms of action of some of the nutraceutical supplements on the mammalian cholesterol pathway are shown in Figure 2. Virtually all studies have shown very high safety profiles ...

platelets express defined immune receptors on their surface and secrete prestored cytokines and chemokines from their granules and thus also attract other immune cells such as macrophages ...

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments ... Transfer of cell-surface antigens by scavenger receptor CD36 promotes thymic tegulatory T cell ...