此前，来自 多伦多大学的研究团队 却颠覆性地发现， 常见益生菌之一的乳杆菌能将膳食中的色氨酸代谢为吲哚，增加肿瘤相关巨噬细胞的活性，从而抑制肿瘤免疫，促进胰腺导管腺肿瘤的生长。 该研究发表在Cell子刊 Immunity 上。

dc.description.abstract: The cytochrome P450 superfamily of enzymes are critical in the metabolism of endogenous and exogenous substrates. CYP1A1 and CYP1B1 have been found to be over-expressed in ...

PE (0:0/14:0), an endogenous metabolite of the gut microbiota, exerts protective effects against sepsis-induced intestinal injury by modulating the AHR/CYP1A1 pathway.

This observation was supported by data that revealed no significant differential AHR target genes Cyp1a1 and Cyp1a2 expression in the liver and ileal. However, for TCDF exposure at the short ...

The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem. 2010 Nov ...