Many pathogenic viruses require a specific structure to be infectious, and their proteins form that structure in vivo with remarkable fidelity. The dynamical process by which protein conformations are ...

My laboratory studies the structure and assembly of small DNA viruses. Specifically we are addressing three fundamental control points : 1) how is capsid assembly prevented in the cytoplasm, 2) how do ...

DNA replication techniques such as error-prone PCR or random peptide insertion can be used to generate large AAV libraries with random point mutations in their capsid structure. After screening an ...

Dr. Prevelige was one of the early adopters of HDX MS methodologies in the analysis of viral structure and assembly. More information on Dr. Prevelige’s work can be found here. Cortines JR, Monroe EB, ...

They also detailed the interactions between the two strands of the helical structure. A molecule that serves as the genetic material for certain viruses, including influenza. It is single-stranded and ...

The award also recognizes related work surrounding gaining a new understanding of the structure and function of HIV’s capsid protein. Despite decades of advancements, HIV continues to infect ...

To achieve this, the team has developed a new methodology using artificial intelligence tools, based on protein structure prediction, to predict the efficiency and stability of the new capsid.