Psoriasis is a multifactorial immune-mediated inflammatory disease. Its pathogenesis involves abnormal accumulation of neutrophils and T-cell related abnormalities. Pyroptosis is a type of regulated ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

An important step in the signaling cascade triggered by them is the cleavage of the protein gasdermin D (GSDMD). The active part of GSDMD, the so-called N-terminal domain (NTD), can then form ...

8月19日，中国科学院成都生物研究所生物资源利用中心王飞研究团队联合四川大学化学学院冯小明院士和董顺喜教授团队在药物化学国际顶级期刊Journal of Medicinal Chemistry上发表题为“Discovery of a Covalent Inhibitor of Pro-Caspase-1 Zymogen Blocking NLRP3 Inflammasome Activation ...

For example, researchers will measure cell death to determine a drug’s anticancer effectiveness. Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark ...

Here’s how it works. Fable 4, also currently just known as Fable, is a reboot of a beloved trilogy of fantasy action role-playing games (RPGs) originally developed by Lionhead Studios.

最终，DMB脱颖而出。通过体外实验，他们发现DMB可以在没有激活Caspase酶的情况下，直接促进GSDMD孔道的形成，诱导肿瘤细胞发生焦亡。 更重要的是 ...

Here’s how it works. "The first three 'Witchers' were by definition a trilogy, so we simply could not name the next game 'The Witcher 4'," Kiciński said in an interview. "This does not mean ...

从狩猎伙伴到家庭成员，狗的温顺、忠诚和善解人意，使它们赢得无数“铲屎官”的心。然而，近年来，随着一系列恶犬伤人事件的频繁发生，这一和谐景象背后隐藏的健康风险也逐渐浮出水面，引起了社会各界的广泛关注和深入讨论。对狂犬病毒的研究与防控，也成为了公共卫生领 ...

Radio 4 is a station for anyone interested in intelligent speech. Its schedule is packed with the most insightful journalism, the wittiest comedy, the most fascinating features and the most ...