Drugs acting on the cholinergic system can improve or worsen cognitive abilities, and their effects are particularly pronounced in frail elderly individuals and patients with Alzheimer disease.

the authors suggest that cholinergic modulating drugs might improve ataxia and possibly other symptoms in patients with MSA-C or SCA3.

In 2024, multiple drugs received complete response letters (CRLs), sometimes unrelated to the safety and efficacy of the drug ...

Although bronchial hyperresponsiveness to cholinergic agents is a main feature of asthma, the role of anticholinergic drugs in chronic asthma management has been largely underestimated.

Consequently, combination therapy currently involves the administration of one cholinergic drug (donepezil, galantamine or rivastigmine) and one glutamatergic drug (memantine). There have been no ...

Discover groundbreaking research on how chronic alcohol use affects cognitive flexibility and brain signaling circuits, ...

Role of the cholinergic system in attention: Considerable research has demonstrated that the ... Greg Smith to develop computational models to predict drug-induced changes in performance in ...

Potentiates neuromuscular blockers (eg, succinylcholine), cholinesterase inhibitors, cholinergic agonists (eg, bethanechol). Antagonizes anticholinergics. Caution with drugs that slow heart rate.